R. Song

Curved light sheet microscopy for centimeter-scale cleared tissues imaging

The paper introduces a curved light sheet microscope for high-throughput imaging of cleared tissues, achieving diffraction-limited resolution over a large field of view.

Commensal bacteria inhibit viral infections via a tryptophan metabolite

The paper identifies a mechanism by which commensal bacteria inhibit viral infections through a tryptophan metabolite that activates the aryl hydrocarbon receptor.

NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model

This study shows NPRL2 gene therapy reduces lung metastases in KRAS/STK11 mutant NSCLC in humanized mice by enhancing immune cell infiltration and reducing T cell inhibitory signals.

Structural basis for Retriever-SNX17 assembly and endosomal sorting

This study determines the structure of the Retriever-SNX17 complex using cryo-EM, revealing how SNX17 interacts with Retriever to facilitate endosomal sorting of cargo proteins.

A Simple and Rapid Protocol for the Isolation of Murine Bone Marrow Suitable for the Differentiation of Dendritic Cells

This paper introduces a centrifugation-based method for isolating murine bone marrow to differentiate dendritic cells, which increases cell numbers and yields more type 1 conventional dendritic cells.

Exclusion of PD-1 from the immune synapse: a novel strategy to modulate T cell function

This paper shows that anti-PD-1 antibodies enhance T cell activation by removing PD-1 from the immune synapse, suggesting a new strategy for cancer immunotherapy.

Building on-chip cytoskeletal circuits via branched microtubule networks

This paper develops a microfluidic platform to engineer microtubule circuits by integrating microfabrication with microtubule branching reactions, enabling controlled MT architecture for on-chip applications.

Latent human herpesvirus 6 is reactivated in chimeric antigen receptor T cells

The paper identifies HHV-6 reactivation in CAR T cells using single-cell sequencing and links it to clinical neurotoxicity observed in patients.

Reduced Neutralization of SARS-CoV-2 Omicron Variant in Sera from SARS-CoV-1 Survivors after 3-dose of Vaccination

This study shows that SARS-CoV-1 survivors vaccinated with ZF2001 have reduced neutralization against SARS-CoV-2 Omicron compared to other variants.

A local translation program regulates centriole amplification in the airway epithelium

This study identifies Tnrc6a as a regulator of centriole amplification and multicilia formation through local translation of miRNA targets in airway epithelial cells.

3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib

This study identifies PDK1 as a driver of osimertinib resistance in NSCLC, showing its inhibition sensitizes resistant cells and correlates with disease progression.

A distinct CD115- erythro-myeloid precursor present at the maternal-embryonic interface and in the bone marrow of adult mice

The paper identifies a CD115- macrophage precursor in adult bone marrow that shares features with embryonic erythro-myeloid progenitors and is present at the maternal-embryonic interface.

Therapeutic effect of CT-P59 against SARS-CoV-2 South African variant

This study evaluates CT-P59's efficacy against SARS-CoV-2 variants, showing reduced in vitro neutralization but effective in vivo therapeutic potential against the B.1.351 variant.

circMRPS35 promotes malignant progression and cisplatin resistance in hepatocellular cancer

This study identifies circMRPS35 as a factor promoting HCC progression and cisplatin resistance through miR-148a-3p sponging and a drug-induced peptide.

Deletion of Letmd1 leads to the disruption of mitochondrial function in brown adipose tissue

This study shows that deleting Letmd1 in mice causes mitochondrial dysfunction in brown adipose tissue, leading to thermogenesis disruption and metabolic disorders.

Inflammation Drives Alternative First Exon usage to Regulate Immune Genes including a Novel Iron Regulated Isoform of Aim2

The paper identifies inflammation-induced alternative first exon usage in immune genes, revealing a novel iron-regulated Aim2 isoform with a 5′UTR iron-responsive element.

Deep learning enables structured illumination microscopy with low light levels and enhanced speed

This paper uses deep learning to improve structured illumination microscopy, reducing image requirements and enabling low-light, high-speed super-resolution imaging.

Moderating Effect of Social Support on Role Conflict and Job Satisfaction Among Nurses with Multiple Roles

This study examines how social support moderates the relationship between role conflicts and job satisfaction among nurses with multiple roles in China.

Impact of Candida auris infection in a neutropenic murine model

This study evaluates the impact of Candida auris infection in neutropenic murine models, finding that neutrophil depletion leads to persistent fungal burden and unique behavioral changes.

Study of the AMP-activated protein kinase role in energy metabolism changes during the postmortem aging of yak longissimus lumborum

This study investigates how AMPK activity and energy metabolism change in yak muscle during postmortem aging using AICAR and STO-609.

Setting off the Alarms: Candida albicans Elicits Pro-Inflammatory Differential Gene Expression in Intestinal Peyer’s Patches

This study shows that CD11c+ phagocytes in Peyer’s patches exhibit differential gene expression in response to Candida albicans, distinguishing between strains and contributing to mucosal barrier protection.