Compromised CDK12 activity causes dependency on the non-essential spliceosome components
S. Pallasaho, A. Gondane, D. Duveau, C. Thomas, M. Loda, H. M. Itkonen
This study shows that compromised CDK12 activity in prostate cancer cells leads to addiction to non-essential spliceosome components and lower DNA methylation, suggesting potential therapeutic targets.
bioRxiv · Dec 7, 2021 · PreprintCancer Biology