Author

S. Bellaousov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. J. Abraham· 1 shared C. G. Ludwig· 1 shared C. Thomas· 1 shared C. Wu· 1 shared D. Duveau· 1 shared D. H. Mathews· 1 shared D. Liu· 1 shared D. N. Ermolenko· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBiophysics

B. J. Abraham

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3 papers

Recent·Most cited

O-GlcNAc regulates gene expression by controlling detained intron splicing

Z.-W. Tan, G. Q. Fei, J. Paulo, S. Bellaousov, S. E. S. Martin, D. Duveau, C. Thomas, S. Gygi, P. Boutz, S. Walker

This study shows O-GlcNAc modification regulates detained intron splicing, affecting gene expression and linking nutrient conditions to transcriptional regulation.

bioRxiv · Mar 27, 2020Cell Biology

CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts

M. L. Insco, B. J. Abraham, S. J. Dubbury, S. Dust, C. Wu, K. Y. Chen, D. Liu, C. G. Ludwig, S. Bellaousov, T. Fabo, T. Henriques, K. Adelman, M. Geyer, P. A. Sharp, R. A. Young, , L. I. Zon

This study identifies CDK13 mutations in melanoma, showing they lead to accumulation of truncated transcripts and poor survival, with a mechanism involving impaired ZC3H14 phosphorylation and PAXT complex recruitment.

bioRxiv · Nov 5, 2019Biophysics

The formation of intramolecular secondary structure brings mRNA ends in close proximity

W.-J. C. Lai, M. Kayedkhordeh, E. V. Cornell, E. Farah, S. Bellaousov, R. Rietmeijer, D. H. Mathews, D. N. Ermolenko

The paper shows that mRNAs from various organisms, including humans, inherently fold into structures bringing their ends within 7 nm, regardless of length, except for specific unstructured sequences.

bioRxiv · Mar 27, 2018Biochemistry