Author

D. E. Siekhaus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Organism:Drosophila· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Organism:yeast· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Gyoergy· 2 shared J. Toshima· 2 shared J. Y. Toshima· 2 shared M. Nagano· 2 shared S. Emtenani· 2 shared A. Bergthaler· 1 shared A. Nakano· 1 shared A. Ratheesh· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

A. Gyoergy

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Author profile →

4 papers

Recent·Most cited

Distinct role of TGN-resident clathrin adaptors for Rab5 activation in the TGN-endosome trafficking pathway

M. Nagano, K. Aoshima, H. Shimamura, D. E. Siekhaus, J. Y. Toshima, J. Toshima

The paper investigates the role of clathrin adaptors in Rab5 activation during TGN-endosome trafficking, showing AP-1 and GGAs have distinct functions in this process.

bioRxiv · Mar 27, 2023 · PreprintCell Biology

The yeast endocytic early/sorting compartment exists as an independent sub-compartment within the trans-Golgi network

J. Y. Toshima, A. Tsukahara, M. Nagano, T. Tojima, D. E. Siekhaus, A. Nakano, J. Toshima

This study identifies the Tlg2p-residing compartment within the trans-Golgi network in yeast as an independent early/sorting compartment for endocytic cargos.

bioRxiv · Nov 21, 2022Cell Biology

A genetic program boosts mitochondrial function to power macrophage tissue invasion

S. Emtenani, E. T. Martin, A. Gyoergy, J. Bicher, J. Wendelin-Genger, T. Koecher, T. Hurd, A. Bergthaler, P. Rangan, D. E. Siekhaus

The paper identifies Atossa as a genetic program that enhances mitochondrial function in Drosophila macrophages to support tissue invasion through increased oxidative phosphorylation.

bioRxiv · Feb 18, 2021Cell Biology

A conserved MFS orchestrates a subset of O-glycosylation to facilitate macrophage dissemination and tissue invasion

K. Valoskova, J. Biebl, M. Roblek, S. Emtenani, A. Gyoergy, M. Misova, A. Ratheesh, K. Shkarina, I. S. B. Larsen, S. Y. Vakhrushev, H. Clausen, D. E. Siekhaus

The paper identifies Minerva, an MFS protein, as a conserved regulator of O-glycosylation that facilitates macrophage dissemination and tissue invasion in Drosophila and vertebrates.

bioRxiv · Sep 12, 2018Cancer Biology