H. Clausen

Growth factor-induced desialylation for the fast control of endocytosis

The paper shows that growth factors induce rapid desialylation of cell surface glycoproteins, enabling reversible changes in glycan structure and function through galectin-mediated endocytosis.

The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

The study shows that O-glycosylation extends the half-life of mouse osteocalcin but not human osteocalcin, highlighting a species difference in hormone regulation.

Endosomal trafficking is required for glycosylation and normal maturation of the Alzheimer's-associated protein sorLA

This study shows that endosomal trafficking is essential for sorLA maturation and shedding, with immature sorLA acquiring complex N-glycans upon retrograde transport.

Glycoengineering of NK cells with glycan ligands of CD22 and selectins for B-cell lymphoma therapy

This study modifies NK cells with CD22 and selectin glycan ligands to enhance B-cell lymphoma targeting and trafficking, achieving effective tumor suppression in a xenograft model.

The Glyco-enzyme adaptor GOLPH3 Links Intra-Golgi Transport Dynamics to Glycosylation Patterns and Cell Proliferation

This study shows GOLPH3 regulates glycosylation and cell proliferation by controlling glyco-enzyme recycling and lysosomal degradation.

ER transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, Cellular Adherence and Embryonic Gastrulation

This study shows TMTC3 enables O-mannosylation of E-cadherin, affecting cell adhesion and gastrulation, and links TMTC3 mutations to Cobblestone lissencephaly.

A conserved MFS orchestrates a subset of O-glycosylation to facilitate macrophage dissemination and tissue invasion

The paper identifies Minerva, an MFS protein, as a conserved regulator of O-glycosylation that facilitates macrophage dissemination and tissue invasion in Drosophila and vertebrates.