A. Nakano

Brassinosteroids function as the plant male and female reproductive hormone coordinating gene expression.

This study shows that brassinosteroids (BRs) function as reproductive hormones in Arabidopsis, regulating gene expression in both male and female reproductive tissues during fertilization.

Rapid Vacuolar Sorting of the Borate Transporter BOR1 Requires the Adaptor Protein Complex AP-4 in Arabidopsis

This study shows that AP-4 is required for rapid vacuolar sorting of the borate transporter BOR1 in Arabidopsis under high-B conditions.

RudLOV-a new optically synchronized cargo transport method reveals unexpected effect of dynasore

The paper introduces RudLOV, an optical method for synchronized cargo release, revealing dynasore's differential effects on early and late Golgi transport.

ER-to-Golgi trafficking via a dynamic intermediate cis-Golgi tubular network in Arabidopsis

This study identifies the ERGIC in Arabidopsis as a dynamic, Golgi-independent tubular network that generates stable cisternae-like Golgi structures through sphingolipid acyl-chain length regulation.

Presence of the ER-Golgi intermediate compartment that matures into the Golgi in yeast

The paper identifies and characterizes the ER-Golgi intermediate compartment in yeast using live-cell imaging, showing its maturation into the Golgi.

Remodeling of the secretory pathway is coordinated with de novo membrane formation in budding yeast gametogenesis

The paper shows that ERES regeneration in budding yeast spores facilitates PSM growth by promoting Golgi reassembly after a transient stall in membrane traffic.

Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy

The paper maps fetal metabolism during mid-to-late gestation in normal and diabetic pregnancies, identifying metabolic changes due to maternal hyperglycemia.

Mechanism of ATP hydrolysis dependent rotation of ATP synthases

The paper uses cryo-EM to capture catalytic intermediates of ATP synthase F1 domain, revealing how ATP hydrolysis couples to mechanical rotation in 120-degree steps.

Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in GIST cells

This study identifies the molecular mechanisms by which mutant KIT remains in the Golgi and activates oncogenic signaling in GIST cells.

The yeast endocytic early/sorting compartment exists as an independent sub-compartment within the trans-Golgi network

This study identifies the Tlg2p-residing compartment within the trans-Golgi network in yeast as an independent early/sorting compartment for endocytic cargos.

Antiviral effect of candies containing persimmon-derived tannin against SARS-CoV-2 delta strain

This study shows that candies with persimmon-derived tannin reduce SARS-CoV-2 delta variant titers in saliva from healthy volunteers and patients with COVID-19.

Cardio PyMEA: A user-friendly, open-source Python application for cardiomyocyte microelectrode array analysis

Cardio PyMEA provides a user-friendly, open-source Python tool for analyzing cardiomyocyte microelectrode array data, offering customizable functionalities and cross-platform accessibility.

Structural snapshots of V/A-ATPase reveal a new paradigm for rotary catalysis

The paper determines atomic models of V/A-ATPase catalytic intermediates, revealing a ratchet-like mechanism for unidirectional rotation instead of a power stroke model.

Building new compartments for unconventional protein secretion from the early and late Golgi membranes

The paper identifies CUPS and TCUPS as compartments involved in unconventional protein secretion, showing their dynamics and relationship to the Golgi during starvation.

Liquid-liquid phase separation of florigen activation complex induces flowering

This study shows that the florigen activation complex (FAC) undergoes liquid-liquid phase separation, which is essential for flowering in plants.

TGN/EE SNARE protein SYP61 is ubiquitinated and required for carbon/nitrogen-nutrient responses in Arabidopsis

This study identifies SYP61 as a ubiquitinated SNARE protein in Arabidopsis, showing its role in nutrient stress responses and trafficking.

Switching secretory pathway direction for organelle acquisition in plants

The paper identifies a mechanism in liverworts for acquiring oil bodies through switching secretory pathway direction during cellular phase transitions.

The Glyco-enzyme adaptor GOLPH3 Links Intra-Golgi Transport Dynamics to Glycosylation Patterns and Cell Proliferation

This study shows GOLPH3 regulates glycosylation and cell proliferation by controlling glyco-enzyme recycling and lysosomal degradation.

A non-canonical unfolded protein response pathway and mitochondrial dynamics control the number of ER-mitochondria contact sites

This study identifies a novel role of mitochondrial dynamics in regulating ER-mitochondria contact sites in yeast, showing that ER stress affects ERMES cluster stability independently of the canonical UPR pathway.

Inoculum size effects in blaIMP-6 and plasmid-mediated quinolone resistance gene-positive Enterobacteriaceae in Japan

This study examines resistance genes and inoculum size effects in IMP-6 MBL-producing Enterobacteriaceae with reduced susceptibility to fluoroquinolones and amikacin in Japan.