Author

D. Fasci

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

A. C. Rios· 1 shared A. Cleven· 1 shared A. D. Meringa· 1 shared A. J. R. Heck· 1 shared A. K. L. Wezenaar· 1 shared A. M. M. Eggermont· 1 shared B. V. Eckhardt· 1 shared D. I. Svergun· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. C. Rios

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF

I. Corbeski, X. Guo, B. V. Eckhardt, D. Fasci, W. W. Wiegant, M. Graewert, K. Vreeken, H. Wienk, D. I. Svergun, A. J. R. Heck, H. van Attikum, R. Boelens, T. K. Sixma, F. Mattiroli, H. van Ingen

The paper shows that the acidic domain of APLF assembles histone octamers and deposits them onto DNA to form nucleosomes.

bioRxiv · Dec 24, 2021Biochemistry

Behavioral-transcriptomic landscape of engineered T cells targeting human cancer organoids

J. F. Dekkers, M. Alieva, A. Cleven, F. Keramati, P. Brazda, H. G. Rebel, A. K. L. Wezenaar, J. Puschhof, M.-B. Buchholz, M. Barrera Roman, I. Johanna, A. D. Meringa, D. Fasci, M. H. Geurts, H. C. R. Ariese, , A. C. Rios

The paper develops BEHAV3D, a 3D imaging-transcriptomics platform to study T cell behavior and molecular mechanisms in cancer organoids, identifying a super engager cluster with unique gene signatures and IFN-I priming capabilities.

bioRxiv · May 5, 2021Cancer Biology