A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection
D. B. Heisler, K. A. Johnson, M. B. Ohlson, D. H. Ma, L. Zhang, M. Tran, C. D. Corley, M. E. Abrams, J. G. McDonald, J. W. Schoggins, N. M. Alto, A. Radhakrishnan
This paper identifies a mechanism by which oxysterols like 25HC deplete accessible cholesterol from plasma membranes via ACAT activation and SREBP suppression to restrict microbial infection.
bioRxiv · Oct 10, 2022Cell Biology