Author

D. B. Heisler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

N. M. Alto· 2 shared A. Embry· 1 shared A. Radhakrishnan· 1 shared A. White· 1 shared B. L. Kocsis· 1 shared C. D. Corley· 1 shared D. Gammon· 1 shared D. H. Ma· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

N. M. Alto

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Exploiting Bacterial Effector Proteins to Uncover Evolutionarily Conserved Antiviral Host Machinery

A. Embry, N. S. Baggett, D. B. Heisler, A. White, M. F. de Jong, B. L. Kocsis, D. R. Tomchick, N. M. Alto, D. Gammon

The paper identifies evolutionarily conserved host factors that restrict arbovirus replication by using bacterial effector proteins to rescue viral replication in insect cells.

PLOS Pathogens · May 16, 2024Peer-reviewedMicrobiology

A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

D. B. Heisler, K. A. Johnson, M. B. Ohlson, D. H. Ma, L. Zhang, M. Tran, C. D. Corley, M. E. Abrams, J. G. McDonald, J. W. Schoggins, N. M. Alto, A. Radhakrishnan

This paper identifies a mechanism by which oxysterols like 25HC deplete accessible cholesterol from plasma membranes via ACAT activation and SREBP suppression to restrict microbial infection.

bioRxiv · Oct 10, 2022Cell Biology