Author

J. W. Schoggins

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

J. L. Eitson· 3 shared M. B. Ohlson· 3 shared A. Kumar· 2 shared C. Xing· 2 shared K. B. Mar· 2 shared M. B. McDougal· 2 shared M. E. Abrams· 2 shared N. M. Alto· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

J. L. Eitson

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Development of a mutant aerosolized ACE2 that neutralizes SARS-CoV-2 in vivo

D. L. Kober, M. C. Caballero Van Dyke, J. L. Eitson, I. N. Boys, M. B. McDougal, D. Rosenbaum, J. W. Schoggins

This paper develops a mutant ACE2 that neutralizes SARS-CoV-2 in vivo through aerosolized delivery, demonstrating its protective effect in a mouse model.

bioRxiv · Sep 26, 2023Microbiology

Interferon inhibits a model RNA virus via a limited set of inducible effector genes

M. B. McDougal, A. M. De Maria, M. B. Ohlson, A. Kumar, C. Xing, J. W. Schoggins

This study identifies a limited set of interferon-stimulated genes that mediate antiviral effects against Venezuelan equine encephalitis virus.

bioRxiv · Feb 21, 2023Microbiology

LY6E protects mice from pathogenic effects of murine coronavirus and SARS-CoV-2

K. B. Mar, M. C. Van Dyke, A. H. Lopez, J. L. Eitson, W. Fan, N. W. Hanners, B. M. Evers, J. M. Shelton, J. W. Schoggins

This study shows LY6E protects mice from murine coronavirus and SARS-CoV-2 by acting in specific immune cells and reducing secretory cell-associated gene expression.

bioRxiv · Jan 25, 2023 · PreprintMicrobiology

Genome-scale CRISPR screening reveals host factors required for ribosome formation and viral replication

M. B. Ohlson, A. Kumar, J. L. Eitson, S. Jang, C. Ni, C. Xing, M. Buszczak, J. W. Schoggins

The paper identifies host factors required for ribosome formation and viral replication using CRISPR screening, showing that SPATA5 and SBDS are broadly needed for multiple virus types.

bioRxiv · Nov 12, 2022Microbiology

A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

D. B. Heisler, K. A. Johnson, M. B. Ohlson, D. H. Ma, L. Zhang, M. Tran, C. D. Corley, M. E. Abrams, J. G. McDonald, J. W. Schoggins, N. M. Alto, A. Radhakrishnan

This paper identifies a mechanism by which oxysterols like 25HC deplete accessible cholesterol from plasma membranes via ACAT activation and SREBP suppression to restrict microbial infection.

bioRxiv · Oct 10, 2022Cell Biology

Over-expression Screen of Interferon-Stimulated Genes Identifies RARRES3 as a Restrictor of Toxoplasma gondii Infection

N. Rinkenberger, M. E. Abrams, S. K. Matta, J. W. Schoggins, N. M. Alto, L. D. Sibley

The paper screens interferon-stimulated genes to identify RARRES3 as a factor restricting Toxoplasma gondii infection by inducing premature parasite egress.

bioRxiv · Sep 4, 2021Microbiology

LY6E impairs coronavirus fusion and confers immune control of viral disease

S. Pfaender, K. B. Mar, E. Michailidis, A. Kratzel, D. Hirt, P. V'kovski, W. Fan, N. Ebert, H. Stalder, H. Kleine-Weber, M. Hoffmann, H. H. Hoffmann, M. Saeed, R. Dijkman, E. Steinmann, , V. Thiel

This study identifies LY6E as an interferon-induced gene that restricts coronavirus entry and pathogenesis by inhibiting spike protein-mediated fusion and protecting immune cells.

Nature Microbiology · Jul 23, 2020Peer-reviewedMicrobiology