Author

N. M. Alto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Organism:mouse· 2 Research Focus:development & morphogenesis· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. E. Abrams· 3 shared A. Embry· 2 shared D. B. Heisler· 2 shared J. W. Schoggins· 2 shared A. Frost· 1 shared A. Radhakrishnan· 1 shared A. White· 1 shared B. L. Kocsis· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCell Biology

M. E. Abrams

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Exploiting Bacterial Effector Proteins to Uncover Evolutionarily Conserved Antiviral Host Machinery

A. Embry, N. S. Baggett, D. B. Heisler, A. White, M. F. de Jong, B. L. Kocsis, D. R. Tomchick, N. M. Alto, D. Gammon

The paper identifies evolutionarily conserved host factors that restrict arbovirus replication by using bacterial effector proteins to rescue viral replication in insect cells.

PLOS Pathogens · May 16, 2024Peer-reviewedMicrobiology

A FACT-ETS-1 Antiviral Response Pathway Restricts Viral Replication and is Countered by Poxvirus A51R Proteins

E. A. Rex, D. Seo, S. Chappidi, C. Pinkham, S. Brito, A. Embry, D. Heisler, Y. Liu, K. Luger, N. M. Alto, F. da Fonseca, R. Orchard, D. Hancks, D. B. Gammon

This study identifies a FACT-ETS-1 antiviral pathway that restricts poxvirus replication and shows how viral A51R proteins counteract it.

bioRxiv · Feb 8, 2023 · PreprintMicrobiology

A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

D. B. Heisler, K. A. Johnson, M. B. Ohlson, D. H. Ma, L. Zhang, M. Tran, C. D. Corley, M. E. Abrams, J. G. McDonald, J. W. Schoggins, N. M. Alto, A. Radhakrishnan

This paper identifies a mechanism by which oxysterols like 25HC deplete accessible cholesterol from plasma membranes via ACAT activation and SREBP suppression to restrict microbial infection.

bioRxiv · Oct 10, 2022Cell Biology

Over-expression Screen of Interferon-Stimulated Genes Identifies RARRES3 as a Restrictor of Toxoplasma gondii Infection

N. Rinkenberger, M. E. Abrams, S. K. Matta, J. W. Schoggins, N. M. Alto, L. D. Sibley

The paper screens interferon-stimulated genes to identify RARRES3 as a factor restricting Toxoplasma gondii infection by inducing premature parasite egress.

bioRxiv · Sep 4, 2021Microbiology

The mechanisms of dynamin-actin interaction

R. Zhang, N. Gerassimov, D. M. Lee, J. R. Jimah, S. Kim, D. Luvsanjav, J. Winkelman, M. Mettlen, M. E. Abrams, R. Kalia, P. Keene, P. Pandey, B. Ravaux, J. H. Kim, J. A. Ditlev, , E. H. Chen

This study identifies a noncanonical role for dynamin in cell-cell fusion by directly bundling actin filaments through GTPase-dependent interactions.

bioRxiv · Mar 25, 2019 · PreprintCell Biology