Author

C. L. Kielkopf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. L. Jenkins· 4 shared E. Glasser· 3 shared M. J. Pulvino· 3 shared C. F. Feeney· 2 shared A. J. Frontier· 1 shared A. J. MacRae· 1 shared A. M. Keedakkatt Puthenpeedikakkal· 1 shared C. Cavender· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersBiochemistry

J. L. Jenkins

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A UHM - ULM interface contributes to U2AF2 and SF3B1 association for pre-mRNA splicing

J. Galardi, V. N. Bela, N. Jeffery, X. He, E. Glasser, S. Loerch, J. L. Jenkins, M. J. Pulvino, P. L. Boutz, C. L. Kielkopf

This study determines the crystal structure of the U2AF2 UHM-SF3B1 ULM interface and shows its role in pre-mRNA splicing and co-regulation with SF1.

bioRxiv · Jan 9, 2022Biochemistry

Pre-mRNA Splicing Factor U2AF2 Recognizes Distinct Conformations of Nucleotide Variants at the Center of the pre-mRNA Splice Site Signal

E. Glasser, D. Maji, G. Biancon, A. M. Keedakkatt Puthenpeedikakkal, C. Cavender, T. Tebaldi, M. J. Pulvino, J. L. Jenkins, D. H. Mathews, S. Halene, C. L. Kielkopf

This study investigates how U2AF2 recognizes different nucleotides at the center of the Py tract in pre-mRNA splice sites using structural and functional analyses.

bioRxiv · Sep 27, 2021Biophysics

A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex

R. Chatrikhi, C. F. Feeney, M. J. Pulvino, G. Alachouzos, A. J. MacRae, Z. Falls, S. Rai, W. W. Brennessel, J. L. Jenkins, M. J. Walter, T. A. Graubert, R. Samudrala, M. S. Jurica, A. J. Frontier, C. L. Kielkopf

The paper identifies a small molecule that inhibits pre-mRNA splicing by stabilizing an early-stage U2AF2-RNA complex, offering a new strategy for targeting spliceosome assembly.

bioRxiv · Sep 28, 2020Biochemistry

A Splice Site-Sensing Conformational Switch in U2AF2 is Modulated by U2AF1 and its Recurrent Myelodysplasia-Associated Mutation

C. L. Kielkopf, D. N. Ermolenko, J. L. Jenkins, K. M. Laird, C. F. Feeney, E. Glasser, C. Warnasooriya

This study investigates how U2AF1 and its S34F mutation affect U2AF2 conformational dynamics and RNA binding using single-molecule FRET.

bioRxiv · Dec 31, 2019Biochemistry