BiochemistrybioRxiv
A Splice Site-Sensing Conformational Switch in U2AF2 is Modulated by U2AF1 and its Recurrent Myelodysplasia-Associated Mutation
C. L. Kielkopf, D. N. Ermolenko, J. L. Jenkins…·C. Warnasooriya
This study investigates how U2AF1 and its S34F mutation affect U2AF2 conformational dynamics and RNA binding using single-molecule FRET.
DOI 10.1093/nar/gkaa293