Author

K. Nakka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. Dilworth· 3 shared A. Sorisky· 2 shared J. McDonald· 2 shared K. Dauner· 2 shared N. Verma· 2 shared X. Zha· 2 shared B.-L. Song· 1 shared C. D. Corley· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCell Biology

J. Dilworth

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Author profile →

3 papers

Recent·Most cited

Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating JMJD3

Z. Saiioum, K. Dauner, Y.-f. Li, N. Verma, V. Almendro-Vedia, D. VALDIVIESO GONZALEZ, D. J. Zhang, K. Nakka, J. McDonald, A. Sorisky, B.-L. Song, I. Lopez Montero, J. Luo, J. Dilworth, X. Zha

This study shows statins reduce macrophage cholesterol, upregulate JMJD3, and shift macrophage activation toward anti-inflammatory responses in both M1 and M2 states.

bioRxiv · Jan 9, 2023Biochemistry

Reducing Cholesterol in Resting Macrophage Activates NF-kB through Mitochondria, Resulting in Epigenomic Reprogramming to Dampen Inflammation in Activated Macrophages

X. Zha, Z. Salloum, K. Dauner, K. Nakka, N. Verma, H. Bandukwala, A. Sorisky, J. Dilworth, D. V. Gonzalez, V. A. Vedia, I. Lopez-Montero, J. McDonald, C. D. Corley

bioRxiv · Feb 10, 2022 · PreprintCell Biology

A Chemical Toolbox for the Study of Bromodomains and Epigenetic Signaling

Q. Wu, D. Heidenreich, S. Zhou, S. Ackloo, G. Deblois, S. Duan, K. Nakka, J. Dilworth, M. Lupien, P. E. Brennan, C. H. Arrowsmith, S. Mueller, O. Fedorov, P. Filippakopoulos, S. Knapp

The paper presents a set of 25 chemical probes targeting human bromodomains and demonstrates their utility in studying muscle cell differentiation and triple negative breast cancer.

bioRxiv · Aug 14, 2018Cell Biology