Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis
M. S. Kaiser, G. Milan, S. Lin, F. Oliveri, K. Chojnowska, L. A. Tintignac, N. Mittal, C. E. Zimmerli, D. J. Glass, M. Zavolan, D. J. Ham, M. A. Ruegg
The paper reveals that mTORC1 promotes muscle atrophy by enhancing the ubiquitin-proteasome system through dual mechanisms, while also showing that proteome integrity depends on ubiquitination.
bioRxiv · Nov 16, 2021Physiology