Small molecule SWELL1-LRRC8 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes
S. K. Gunasekar, L. Xie, P. R. Chheda, C. Kang, D. M. Kern, C. My-Ta, A. Kumar, J. M. Maurer, E. E. Gerber, W. J. Grzesik, M. Elliot-Hudson, Y. Zhang, C. A. Kulkarni, I. Samuel, J. K. Smith, , R. Sah
This study identifies small molecule modulators of the SWELL1-LRRC8 complex that improve glycemic control and prevent NAFLD in murine T2D by restoring insulin signaling and secretion.
Nature Communications · Feb 10, 2022Peer-reviewedPhysiology