Author

S. K. Gunasekar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:metabolism & bioenergetics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:wet-lab / biochemical assay· 2

Frequent Co-Authors

L. Xie· 4 shared R. Sah· 4 shared A. Kumar· 3 shared C. Kang· 3 shared J. M. Maurer· 3 shared A. W. Norris· 2 shared C. E. Grueter· 2 shared M. Elliot-Hudson· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersCell Biology

L. Xie

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Small molecule SWELL1-LRRC8 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes

S. K. Gunasekar, L. Xie, P. R. Chheda, C. Kang, D. M. Kern, C. My-Ta, A. Kumar, J. M. Maurer, E. E. Gerber, W. J. Grzesik, M. Elliot-Hudson, Y. Zhang, C. A. Kulkarni, I. Samuel, J. K. Smith, , R. Sah

This study identifies small molecule modulators of the SWELL1-LRRC8 complex that improve glycemic control and prevent NAFLD in murine T2D by restoring insulin signaling and secretion.

Nature Communications · Feb 10, 2022Peer-reviewedPhysiology

The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS-mTOR signaling and vascular function

A. F. Alghanem, C. Ta, J. M. Maurer, S. K. Gunasekar, A. Kumar, U. Fatima, C. Kang, L. Xie, O. Adeola, J. Abello, M. Riker, M. Elliot-Hudson, R. A. Minerath, A. Stratman, C. E. Grueter, , R. Sah

This study shows that SWELL1 regulates endothelial AKT-eNOS and mTOR signaling, affecting vascular function and contributing to hypertension and vascular narrowing in Type 2 diabetes.

bioRxiv · Aug 4, 2020Cell Biology

SWELL1-LRRC8 complex regulates skeletal muscle cell size, intracellular signalling, adiposity and glucose metabolism

A. Kumar, L. Xie, C. M. Ta, A. J. Hinton, S. K. Gunasekar, R. A. Minerath, K. Shen, J. M. Maurer, C. E. Grueter, E. D. Abel, G. Meyer, R. Sah

This study identifies the SWELL1-LRRC8 complex as a mechanosensor regulating skeletal muscle size, signaling, adiposity, and glucose metabolism through PI3K-AKT-mTOR pathways.

bioRxiv · Jun 4, 2020Cell Biology

SWELL1 is a glucose sensor required for β-cell excitability and insulin secretion

C. Kang, S. K. Gunasekar, A. Mishra, L. Xie, Y. Zhang, S. Pai, Y. Gao, A. W. Norris, S. B. Stephens, R. Sah

This study identifies SWELL1 as a glucose sensor in β-cells that links glucose-induced swelling to chloride current activation, which is required for glucose-stimulated insulin secretion.

bioRxiv · Jun 24, 2017Cell Biology