Author

E. B. Taylor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Physiology· 3 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 7 Assay:metabolomics· 6 Research Focus:cell type annotation· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Rauckhorst· 3 shared A. J. Rauckhorst· 2 shared J. A. Maschek· 2 shared J. E. Cox· 2 shared A. A. A. Cluntun· 1 shared A. D. Pewa· 1 shared A. Kumar· 1 shared A. Q. King-McAlpin· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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3 shared papersBiochemistry

A. Rauckhorst

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Author profile →

8 papers

Recent·Most cited

3-hydroxykynurenine is a ROS-inducing cytotoxic tryptophan metabolite that disrupts the TCA cycle

J. L. Buchanan, A. Rauckhorst, E. B. Taylor

This study identifies 3-hydroxykynurenine as a cytotoxic tryptophan metabolite that disrupts the TCA cycle and induces ROS-mediated apoptosis in colon cancer cells.

bioRxiv · Jul 10, 2023 · PreprintBiochemistry

Hepatic IRE1 Protects Against Septic Cardiac Failure

M. Li, R. R. Berton, Q. Qian, J. A. Maschek, B. Chen, E. Barroso, A. Rauckhorst, T. S. Griffith, E. B. Taylor, J. E. Cox, V. P. Badovinac, G. S. Hotamisligil, L.-s. Song, L. Yang

This study shows that hepatic IRE1 protects against septic cardiac failure by maintaining lipid metabolic balance, independent of inflammation.

bioRxiv · Mar 14, 2023 · PreprintPathology

Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury

A. Rauckhorst, G. V. Martinez, G. M. Andrade, H. Wen, J. Y. Kim, A. Simoni, K. A. Mapuskar, P. Rastogi, E. J. Steinbach, M. L. McCormick, B. G. Allen, A. R. Jackson, N. S. Pabla, M. C. Coleman, D. R. Spitz, , D. Zepeda-Orozco

The paper shows that reducing mitochondrial pyruvate carrier activity in kidney tubular cells protects against acute kidney injury by enhancing redox defenses and survival.

bioRxiv · Jan 31, 2023Biochemistry

Phosphatidylethanolamine facilitates mitochondrial pyruvate entry to regulate metabolic flexibility

P. Siripoksup, G. Cao, A. A. A. Cluntun, J. A. Maschek, Q. Pearce, M. J. Lang, H. Eshima, P. C. Opurum, Z. S. Mahmassani, E. B. Taylor, J. E. Cox, M. J. Drummond, J. Rutter, K. Funai

This study identifies phosphatidylethanolamine's role in regulating mitochondrial pyruvate entry, linking it to metabolic flexibility in skeletal muscle.

bioRxiv · Nov 1, 2022 · PreprintPhysiology

Mouse tissue harvest-induced hypoxia rapidly alters the in vivo metabolome, between-genotype metabolite level differences, and 13C-tracing enrichments

A. J. Rauckhorst, N. Borcherding, D. J. Pape, A. S. Kraus, D. A. Scerbo, E. B. Taylor

The paper shows that post-dissection hypoxia rapidly alters the metabolome, genotype-specific differences, and 13C-tracing enrichments in mouse tissues.

bioRxiv · Jun 7, 2022Biochemistry

Small molecule SWELL1-LRRC8 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes

S. K. Gunasekar, L. Xie, P. R. Chheda, C. Kang, D. M. Kern, C. My-Ta, A. Kumar, J. M. Maurer, E. E. Gerber, W. J. Grzesik, M. Elliot-Hudson, Y. Zhang, C. A. Kulkarni, I. Samuel, J. K. Smith, , R. Sah

This study identifies small molecule modulators of the SWELL1-LRRC8 complex that improve glycemic control and prevent NAFLD in murine T2D by restoring insulin signaling and secretion.

Nature Communications · Feb 10, 2022Peer-reviewedPhysiology

Large1 Gene Transfer in Older myd Mice with Severe Muscular Dystrophy Restores Muscle Function and Greatly Improves Survival

T. Yonekawa, A. J. Rauckhorst, S. Y. El-Hattab, M. A. Cuellar, D. Venzke, M. E. Anderson, H. Okuma, A. D. Pewa, E. B. Taylor, K. P. Campbell

This study shows that gene transfer using AAV2/9 CMV Large1 in older myd mice with severe muscular dystrophy restores muscle function and significantly improves survival.

bioRxiv · Oct 28, 2021Physiology

NADPH and glutathione redox link TCA cycle activity to endoplasmic reticulum stress

E. R. Gansemer, K. S. McCommis, M. Martino, A. Q. King-McAlpin, M. J. Potthoff, B. N. Finck, E. B. Taylor, D. T. Rutkowski

The paper shows that TCA cycle activity influences ER stress via NADPH and glutathione redox metabolism in mouse hepatocytes.

bioRxiv · Oct 29, 2019Cell Biology