Author

J. K. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. N. Freiberg· 2 shared B. Lee· 2 shared T. Juelich· 2 shared A. Kumar· 1 shared A. L. Routh· 1 shared A. Muruato· 1 shared A. Vanderheiden· 1 shared A. W. Norris· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

A. N. Freiberg

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structural and Dynamic Basis of DNA Capture and Translocation by Mitochondrial Twinkle Helicase

Z. Li, P. Kaur, C.-Y. Lo, N. Chopra, J. K. Smith, H. Wang, Y. Gao

This study uses cryo-EM and HS-AFM to determine the structure of Twinkle helicase and reveals its DNA capture and translocation mechanism, highlighting disease-related mutations and stochastic ATP hydrolysis.

bioRxiv · Aug 11, 2022Biochemistry

Small molecule SWELL1-LRRC8 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes

S. K. Gunasekar, L. Xie, P. R. Chheda, C. Kang, D. M. Kern, C. My-Ta, A. Kumar, J. M. Maurer, E. E. Gerber, W. J. Grzesik, M. Elliot-Hudson, Y. Zhang, C. A. Kulkarni, I. Samuel, J. K. Smith, , R. Sah

This study identifies small molecule modulators of the SWELL1-LRRC8 complex that improve glycemic control and prevent NAFLD in murine T2D by restoring insulin signaling and secretion.

Nature Communications · Feb 10, 2022Peer-reviewedPhysiology

Nipah virus Bangladesh infection elicits organ-specific innate and inflammatory responses in the marmoset model

C. S. Stevens, J. Lowry, T. Juelich, C. Atkins, K. Johnson, J. K. Smith, M. Panis, T. Ikegame, B. tenOever, A. N. Freiberg, B. Lee

This study investigates NiV Bangladesh infection in marmosets, revealing organ-specific innate and inflammatory responses through RNA-seq analysis.

bioRxiv · Oct 11, 2021Microbiology

Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis

B. A. Johnson, X. Xie, B. Kalveram, K. G. Lokugamage, A. Muruato, J. Zou, X. Zhang, T. Juelich, J. K. Smith, L. Zhang, C. Schindewolf, M. N. Vu, A. Vanderheiden, J. A. Plante, K. S. Plante, , V. D. Menachery

This study shows that removing the furin cleavage site from SARS-CoV-2 increases replication in Vero cells but reduces replication in respiratory cells and pathogenesis in hamsters, while also decreasing neutralization susceptibility.

bioRxiv · Aug 26, 2020 · PreprintMicrobiology

Effects of endophyte infected tall fescue seed and red clover isoflavones on rumen microbial populations, fiber fermentation, and volatile fatty acids in vitro

E. A. Melchior, J. T. Mulliniks, J. K. Smith, G. E. Bates, L. G. Schneider, Z. D. McFarlane, M. D. Flythe, J. L. Klotz, J. P. Goodman, H. Ji, P. Myer

This study examines how endophyte-infected tall fescue seed and red clover isoflavones affect rumen microbial populations, fiber degradation, and volatile fatty acids in an in vitro system.

bioRxiv · Jul 25, 2018Microbiology