Author

A. W. Norris

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1

Frequent Co-Authors

C. Kang· 2 shared L. Xie· 2 shared R. Sah· 2 shared S. K. Gunasekar· 2 shared Y. Zhang· 2 shared A. Kumar· 1 shared A. Mishra· 1 shared C. A. Kulkarni· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPhysiology

C. Kang

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Author profile →

3 papers

Recent·Most cited

Obesity Disrupts Pituitary UPR Leading to NAFLD

Q. Qian, M. Li, Z. Zhang, S. Davis, K. Rahmouni, A. W. Norris, H. Cao, W.-X. Ding, L. Yang

This study shows obesity disrupts pituitary UPR, leading to NAFLD, and demonstrates that restoring pituitary UPR can ameliorate metabolic defects.

bioRxiv · Jul 6, 2022 · PreprintPhysiology

Small molecule SWELL1-LRRC8 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes

S. K. Gunasekar, L. Xie, P. R. Chheda, C. Kang, D. M. Kern, C. My-Ta, A. Kumar, J. M. Maurer, E. E. Gerber, W. J. Grzesik, M. Elliot-Hudson, Y. Zhang, C. A. Kulkarni, I. Samuel, J. K. Smith, , R. Sah

This study identifies small molecule modulators of the SWELL1-LRRC8 complex that improve glycemic control and prevent NAFLD in murine T2D by restoring insulin signaling and secretion.

Nature Communications · Feb 10, 2022Peer-reviewedPhysiology

SWELL1 is a glucose sensor required for β-cell excitability and insulin secretion

C. Kang, S. K. Gunasekar, A. Mishra, L. Xie, Y. Zhang, S. Pai, Y. Gao, A. W. Norris, S. B. Stephens, R. Sah

This study identifies SWELL1 as a glucose sensor in β-cells that links glucose-induced swelling to chloride current activation, which is required for glucose-stimulated insulin secretion.

bioRxiv · Jun 24, 2017Cell Biology