D. K. Gupta

Rational protein engineering to enhance MHC-independent T cell receptors

The paper designs MHC-independent T cell receptors (miTCRs) to enhance cancer immunotherapy by improving receptor stability and function through structural modeling and iterative sequence modifications.

Myeloid Cell-Derived IL1β Contributes to Pulmonary Vascular Remodeling in Heart Failure with Preserved Ejection Fraction

This study identifies myeloid cell-derived IL1β as a key driver of pulmonary vascular remodeling in HFpEF using a murine model and multi-omics approaches.

The effect of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes

This study investigates the effects of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes using mouse models, revealing allele-specific and tissue-specific molecular requirements for cilia motor assembly.

A common venomous ancestor? Prevalent bee venom genes evolved before the aculeate stinger while few major toxins are bee-specific

The paper investigates the origin of venom genes in hymenopteran insects, finding that most venom proteins predate the evolution of the aculeate stinger and are shared across the clade, with only a few being unique to bees.

Cross-species analysis between the maize smut fungi Ustilago maydis and Sporisorium reilianum highlights the role of transcriptional plasticity of effector orthologs for virulence and disease

This study compares effector gene regulation in two maize smut fungi, showing transcriptional plasticity and functional divergence contribute to disease symptom differences.

Improving the chromosome-level genome assembly of the Siamese fighting fish (Betta splendens) in a university Master's course.

The paper improves the chromosome-level genome assembly of the Siamese fighting fish using long-read nanopore sequencing and HiC scaffolding, demonstrating educational application in a Master's course.