A. Horani

Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy

The paper identifies cellular defects beyond motility loss in ciliopathies caused by CCDC39/CCDC40 variants, showing proteostasis disruption and cell fate switching.

Ultrastructure expansion microscopy (U-ExM) of mouse and human kidneys for analysis of subcellular structures

This paper describes a U-ExM protocol for analyzing subcellular structures in mouse and human kidney tissues with high detail using conventional microscopy.

The effect of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes

This study investigates the effects of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes using mouse models, revealing allele-specific and tissue-specific molecular requirements for cilia motor assembly.

Engineering Rotating Apical-Out Airway Organoid for Assessing Respiratory Cilia Motility

This study develops a rotating apical-out airway organoid model and computational framework to assess cilia motility and its defects in disease states.

Kif9 is an active kinesin motor required for ciliary beating and proximodistal patterning of motile axonemes

This study shows Kif9 is essential for ciliary beating and proper localization of axonemal structures in Xenopus, with both indirect and direct roles in motility.

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

This study identifies H522 cells as ACE2-negative human cells permissive to SARS-CoV-2 infection, revealing alternative receptor usage and host response mechanisms.

The translational landscape of SARS-CoV-2 and infected cells

This study uses ribosome profiling to analyze SARS-CoV-2 and host mRNA translation in infected cells, finding that viral mRNAs are not more efficiently translated than host mRNAs and highlighting unique translational strategies.

Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins

The paper shows that inner and outer dynein arm subunits are partitioned into non-overlapping regions within DynAPs and identifies Daap1 as a novel regulator of ODA deployment.