Author

V. N. Hariharan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Bhatt· 1 shared A. Khvorova· 1 shared A. Singh· 1 shared A. Summer· 1 shared B. Bramato· 1 shared B. Godinho· 1 shared C. Ferguson· 1 shared C. Lochmann· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMicrobiology

A. Bhatt

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2 papers

Recent·Most cited

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

K. Yamada, V. N. Hariharan, J. Caiazzi, R. Miller, C. Ferguson, E. Sapp, H. Fakih, Q. Tan, N. Yamada, R. Furgal, J. Paquette, B. Bramato, N. McHugh, A. Summer, C. Lochmann, , A. Khvorova

This paper introduces exNA, a novel nucleic acid backbone that enhances oligonucleotide stability and efficacy in vivo, showing improved resistance to exonucleases and increased tissue exposure and potency.

bioRxiv · May 26, 2023Biochemistry

The histidine kinase PdtaS is a cyclic di-GMP binding metabolic sensor that controls mycobacterial adaptation to nutrient deprivation

V. N. Hariharan, C. Thakur, A. Singh, R. Gopinathan, D. P. Singh, G. Sankhe, N. Chandran, A. Bhatt, D. K. Saini

The paper identifies PdtaS as a c-di-GMP binding histidine kinase that regulates mycobacterial adaptation to nutrient deprivation through transcriptional and metabolic changes.

bioRxiv · Apr 23, 2019 · PreprintMicrobiology