D. L. Kaplan

Engineered autocrine signaling eliminates muscle cell FGF2 requirements for cultured meat production

This study engineers muscle cells to eliminate the need for costly FGF2 in cultured meat production by enabling autocrine signaling.

Immortalized bovine satellite cells for cultured meat applications

This paper develops genetically immortalized bovine satellite cells for cultured meat production, achieving over 120 doublings while maintaining myogenic differentiation capacity.

A Beefy-R culture medium: replacing albumin with rapeseed protein isolates

The paper replaces recombinant albumin in a serum-free medium with rapeseed protein isolate to create a low-cost, sustainable alternative for culturing bovine satellite cells.

Continuous Fish Muscle Cell Line with Capacity for Myogenic and Adipogenic-like Phenotypes

The paper establishes and characterizes a continuous Atlantic mackerel skeletal muscle cell line with myogenic and adipogenic-like phenotypes.

Three-dimensional humanized gingival tissue model to study oral microbiome

This paper develops a 3D humanized gingival tissue model to study oral microbiome interactions and host-pathogen imbalances in periodontal disease.

Macroscale Adipose Tissue from Cellular Aggregates: A Simplified Method of Mass Producing Cell-Cultured Fat for Food Applications

This paper describes a method to produce bulk cell-cultured fat tissue for food applications by aggregating adipocytes into 3D structures using binders, resulting in fat with similar texture and mechanical properties to animal fat.

Impact of bioactive molecule inclusion in lyophilized silk scaffolds varies between in vivo and in vitro assessments

This paper compares in vitro and in vivo effects of bioactive molecule inclusion in silk scaffolds on degradation, cell infiltration, and tissue deposition.

Simple and effective serum-free medium for sustained expansion of bovine satellite cells for cell cultured meat

This paper develops a serum-free medium for bovine satellite cells, enabling long-term expansion without losing myogenicity.