Author

D. Le Roy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

T. Roger· 2 shared A. C.-A. Zwygart· 1 shared A. N. R. Weber· 1 shared A. Tondervik· 1 shared B. Hube· 1 shared B. Moerschbacher· 1 shared C. Fage· 1 shared C. Medaglia· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

T. Roger

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Author profile →

2 papers

Recent·Most cited

Development of Broad-spectrum β-cyclodextrins-Based Nanomaterials Against Influenza Viruses

A. C.-A. Zwygart, C. Medaglia, Y. Zhu, E. B. Tarbet, J. B. Westover, C. Fage, D. Le Roy, T. Roger, S. Constant, S. Huang, F. Stellacci, P. J. Silva, C. Tapparel

This study develops CD-SA, a β-cyclodextrin-based nanomaterial that acts as a potent broad-spectrum antiviral against influenza A and B viruses, showing higher efficacy than Oseltamivir in ex vivo and in vivo tests.

bioRxiv · Mar 5, 2024Microbiology

Transkingdom mechanism of MAMP generation by chitotriosidase (CHIT1) feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing

T.-H. Chang, Y. C. Gloria, M. J. Hellmann, C.-L. Greve, D. Le Roy, T. Roger, F. Bork, S. Bugl, J. Jakob, L. Kasper, B. Hube, S. Pusch, N. Gow, M. Sorlie, A. Tondervik, , A. N. R. Weber

This study identifies CHIT1 as an enzyme that converts fungal chitin into oligomers sensed by TLR2, revealing a mammalian MAMP generation system similar to plants.

bioRxiv · Feb 17, 2022Immunology