Author

S. Pusch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. von Deimling· 2 shared A. A. Martija· 1 shared A. Christians· 1 shared A. Kopach· 1 shared A. Krauss· 1 shared A. M. Heberle· 1 shared A. N. R. Weber· 1 shared A. Reintjes· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

A. von Deimling

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastoma

A. A. Martija, A. Krauss, N. Baechle, L. Doth, A. Christians, D. Krunic, M. Schneider, D. Helm, R. Will, C. Hartmann, C. Herold-Mende, A. von Deimling, S. Pusch

This study identifies EMP3 as a regulator of EGFR/CDK2 signaling in glioblastoma by stabilizing EGFR and promoting its oncogenic activity.

bioRxiv · May 6, 2023Cancer Biology

Transkingdom mechanism of MAMP generation by chitotriosidase (CHIT1) feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing

T.-H. Chang, Y. C. Gloria, M. J. Hellmann, C.-L. Greve, D. Le Roy, T. Roger, F. Bork, S. Bugl, J. Jakob, L. Kasper, B. Hube, S. Pusch, N. Gow, M. Sorlie, A. Tondervik, , A. N. R. Weber

This study identifies CHIT1 as an enzyme that converts fungal chitin into oligomers sensed by TLR2, revealing a mammalian MAMP generation system similar to plants.

bioRxiv · Feb 17, 2022Immunology

G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules

M. T. Prentzell, U. Rehbein, M. Cadena Sandoval, A.-S. De Meulemeester, R. Baumeister, L. Brohee, B. Berdel, M. Bockwoldt, B. Carroll, A. von Deimling, C. Demetriades, G. Figlia, A. M. Heberle, I. Heiland, B. Holzwarth, , K. Thedieck

This paper shows G3BP1 anchors the TSC complex to lysosomes to suppress mTORC1 signaling without stress granules, and inhibits mTORC1-driven cancer and neuronal issues.

bioRxiv · Apr 16, 2020Cell Biology