Author

D. M. O'Rourke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:CITE-seq· 1

Frequent Co-Authors

Z. A. Binder· 3 shared J. V. Zhang· 2 shared L. Zhang· 2 shared M. P. Nasrallah· 2 shared R. Thokala· 2 shared Y. Yin· 2 shared A. Fathi Kazerooni· 1 shared A. Hatzigeorgiou· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

Z. A. Binder

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The Radiogenomic and Spatiogenomic Landscapes of Glioblastoma, and Their Relationship to Oncogenic Drivers

A. Fathi Kazerooni, H. Akbari, X. Hu, V. Bommineni, D. Grigoriadis, E. Toorens, C. Sako, E. Mamourian, D. Ballinger, R. Sussman, A. Singh, I. I. Verginadis, N. Dahmane, C. Koumenis, Z. A. Binder, , C. Davatzikos

This study identifies imaging and spatial biomarkers in glioblastoma that correlate with molecular features and oncogenic drivers using machine learning on MRI data.

bioRxiv · Dec 15, 2022Bioengineering

Locally secreted BiTEs complement CAR T cells by enhancing solid tumor killing

Y. Yin, J. Rodriguez, N. Li, R. Thokala, M. P. Nasrallah, L. Hu, L. Zhang, J. V. Zhang, D. Kainth, L. Haddad, E. X. Johns, Y. Long, H. Liang, J. Qi, X. Zhang, , D. M. O'Rourke

This study shows that BiTE-secreting T cells outperform CAR T cells in killing glioma cells in vitro and in vivo, with enhanced cytotoxicity and tumor growth delay.

bioRxiv · Jun 8, 2021 · PreprintCancer Biology

High Affinity Chimeric Antigen Receptor with Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms

R. Thokala, Z. A. Binder, Y. Yin, L. Zhang, J. V. Zhang, D. Y. Zhang, M. C. Milone, G.-L. Ming, H. Song, D. M. O'Rourke

This paper develops a CAR T cell with broad EGFR specificity to target multiple tumor clones and reduce antigen loss escape in glioblastoma.

bioRxiv · Feb 4, 2021Cancer Biology