G.-L. Ming

Neuronal interactions in forebrain organoids lead to protective antiviral responses

The paper shows that in 3D forebrain organoids, neurons and neural progenitors use type I interferon signaling to limit viral spread through intercellular communication.

Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae

This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.

Brain-wide neuronal circuit connectome of human glioblastoma

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

Loss-of-function mutation in human Oxidation Resistance gene 1 disrupts the spatial-temporal regulation of histone arginine methylation in early brain development

This study identifies a loss-of-function mutation in OXR1 causing neurodevelopmental disorders and shows its role in regulating histone arginine methylation in brain organoids.

High Affinity Chimeric Antigen Receptor with Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms

This paper develops a CAR T cell with broad EGFR specificity to target multiple tumor clones and reduce antigen loss escape in glioblastoma.

Generation and biobanking of patient-derived glioblastoma organoids and their application in CAR-T cell testing

This paper describes methods for generating and biobanking glioblastoma organoids from patient tissue and testing CAR-T cell responses through co-culture.

An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication

The paper identifies the proteasome as critical for ZIKV and DENV replication through three systems biology approaches and finds proteasome inhibitors suppress both viruses.