High Affinity Chimeric Antigen Receptor with Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms
R. Thokala, Z. A. Binder, Y. Yin, L. Zhang, J. V. Zhang, D. Y. Zhang, M. C. Milone, G.-L. Ming, H. Song, D. M. O'Rourke
This paper develops a CAR T cell with broad EGFR specificity to target multiple tumor clones and reduce antigen loss escape in glioblastoma.
bioRxiv · Feb 4, 2021Cancer Biology