Author

M. J. Lenardo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:clinical cohort / trial· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

H. Matthews· 2 shared H. Su· 2 shared V. K. Rao· 2 shared Y. Zhang· 2 shared A. Alazami· 1 shared A. F. Carisey· 1 shared A. J. Faruqi· 1 shared A. K. Boddapati· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

H. Matthews

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Author profile →

4 papers

Recent·Most cited

Human immunodeficiency reveals GIMAP5 as lymphocyte-specific regulator of senescence

A. Y. Park, M. Leney-Greene, M. Lynberg, X. Xu, L. Zheng, Y. Zhang, H. Matthews, B. Chao, A. Morawski, P. Jiang, J. Aluri, E. K. Aydine, A. Kiykim, J. Pascall, I. Barlan, , M. J. Lenardo

This study identifies GIMAP5 as a lymphocyte-specific regulator of senescence, showing that rapamycin can restore naive T cell levels in GIMAP5-deficient patients.

bioRxiv · Feb 22, 2021 · PreprintImmunology

Human plasma-like medium improves T lymphocyte activation

M. A. Leney-Greene, A. K. Boddapati, H. Su, J. Cantor, M. J. Lenardo

This study compares T lymphocyte activation in human plasma-like medium to RPMI with dialyzed FBS, finding significant transcriptional differences and calcium-dependent effects on activation.

bioRxiv · Aug 21, 2019Immunology

Genetic immunodeficiency and autoimmune disease reveal distinct roles of Hem1 in the WAVE2 and mTORC2 complexes

W. A. Comrie, M. C. Poli, S. A. Cook, M. Similuk, A. Oler, A. J. Faruqi, D. B. Kuhns, S. Yang, A. F. Carisey, B. Fournier, D. E. Anderson, S. Price, W. A. Chahla, A. Vargas-Hernandez, L. R. Forbes, , M. J. Lenardo

Hem1 loss-of-function mutations cause congenital immunodysregulation by disrupting WAVE2 and mTORC2 complexes, leading to immunodeficiency and immune hyperresponsiveness.

bioRxiv · Jul 4, 2019 · PreprintImmunology

Human IL-2 receptor β mutations associated with defects in immunity and peripheral tolerance

Z. Zhang, F. Gothe, P. Pennamen, J. James, D. MacDonald, C. P. Mata, Y. Modis, M. Acres, W. Haller, C. Bowen, R. Doffinger, J. Sinclair, S. Brothers, A. Alazami, Y. Zhang, , M. J. Lenardo

This study identifies IL-2Rβ gene mutations causing immune and tolerance defects, showing variable expression impacts on T and NK cells and informing IL-2-based therapies.

bioRxiv · Nov 26, 2018Immunology