Author

C. F. Feeney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. L. Kielkopf· 2 shared J. L. Jenkins· 2 shared A. J. Frontier· 1 shared A. J. MacRae· 1 shared C. Warnasooriya· 1 shared D. N. Ermolenko· 1 shared E. Glasser· 1 shared G. Alachouzos· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

C. L. Kielkopf

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2 papers

Recent·Most cited

A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex

R. Chatrikhi, C. F. Feeney, M. J. Pulvino, G. Alachouzos, A. J. MacRae, Z. Falls, S. Rai, W. W. Brennessel, J. L. Jenkins, M. J. Walter, T. A. Graubert, R. Samudrala, M. S. Jurica, A. J. Frontier, C. L. Kielkopf

The paper identifies a small molecule that inhibits pre-mRNA splicing by stabilizing an early-stage U2AF2-RNA complex, offering a new strategy for targeting spliceosome assembly.

bioRxiv · Sep 28, 2020Biochemistry

A Splice Site-Sensing Conformational Switch in U2AF2 is Modulated by U2AF1 and its Recurrent Myelodysplasia-Associated Mutation

C. L. Kielkopf, D. N. Ermolenko, J. L. Jenkins, K. M. Laird, C. F. Feeney, E. Glasser, C. Warnasooriya

This study investigates how U2AF1 and its S34F mutation affect U2AF2 conformational dynamics and RNA binding using single-molecule FRET.

bioRxiv · Dec 31, 2019Biochemistry