The spindle orienting machinery requires activation, not just localization
K. E. Neville, T. M. Finegan, N. Lowe, P. M. Bellomio, D. Na, D. T. Bergstralh
This study shows that spindle orientation requires both Pins localization and activation, with Discs large mediating activation, challenging the canonical model that only localization determines orientation.
EMBO Reports · Mar 6, 2023Peer-reviewedCell Biology