J. Gsponer

Analysis of protein levels and solubility in distinct brain regions reveals several elements of the protein homeostasis network that are impacted by aging

The paper analyzes protein levels and solubility in brain regions of aged mice, revealing age-related changes in proteostasis and inflammation markers.

Shift of the insoluble content of the proteome in aging mouse brain

This study identifies age-related changes in the insoluble proteome of mouse brains, showing a shift in protein characteristics associated with proteostasis decline.

Insulin receptor trafficking and interactions in muscle cells

This study investigates insulin receptor trafficking and interactions in muscle cells, identifying caveolin and clathrin-mediated pathways involved in receptor dynamics.

Pulse labeling reveals the tail end of protein folding by proteome profiling

The paper identifies newly translated proteins that require more time to fold by analyzing their thermostability under heat stress using pulse SILAC and mass spectrometry.

Dynamic phase separation of the androgen receptor and its coactivators to regulate gene expression.

This study shows that androgen receptor (AR) and its co-activator MED1 form dynamic, AR-rich condensates at superenhancers in prostate cancer, which are crucial for oncogenic gene expression.

Proteomic analysis reveals the recruitment of intrinsically disordered regions to stress granules

The paper identifies heat-regulated yeast proteins that localize to stress granules, showing intrinsically disordered regions (IDRs) are sufficient for SG recruitment and play a critical role in heat-stress response.

Widespread alteration of protein autoinhibition in human cancers

The paper identifies cancer-specific mutations in inhibitory allosteric switches across multiple cancer types and shows their association with altered signaling and cancer progression.