Dynamic phase separation of the androgen receptor and its coactivators to regulate gene expression.
F. Zhang, S. Wong, J. Lee, S. Lingadahalli, C. Wells, N. Saxena, C. Sanchez, B. Sun, A. K. Parra-Nunez, N. Chan, J. M. Bui, Y. Wang, P. S. Rennie, N. A. Lack, A. Cherkasov, , N. Lallous
This study shows that androgen receptor (AR) and its co-activator MED1 form dynamic, AR-rich condensates at superenhancers in prostate cancer, which are crucial for oncogenic gene expression.
bioRxiv · Mar 27, 2021Cancer Biology