Author

D. Paine-Cabrera

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. Kotulkar· 4 shared U. Apte· 4 shared D. R. Robarts· 2 shared D. Robarts· 2 shared K. K. Venneman· 2 shared C. Lau· 1 shared C. Slawson· 1 shared G. Bial· 1 shared

Activity by Year

2023-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersPathology

M. Kotulkar

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4 papers

Recent·Most cited

Role of HNF4alpha-cMyc Interaction in CDE-diet Induced Liver Injury and Regeneration

M. Kotulkar, J. Barbee, D. Robarts, D. Paine-Cabrera, U. Apte

This study examines the role of HNF4-cMyc interaction in liver injury and regeneration using a CDE diet model, finding that HNF4 deletion increases injury while cMyc deletion decreases it, with combined deletion leading to a unique HPC activation phenotype.

bioRxiv · Nov 27, 2023Pathology

Regulation of Hepatic Xenosensor Function by HNF4alpha

M. Kotulkar, D. Paine-Cabrera, D. Robarts, U. Apte

This study shows that HNF4alpha is essential for the function of CAR, PXR, and PPAR but not AhR in hepatic xenosensor activation.

bioRxiv · Oct 11, 2023Pharmacology & Toxicology

The Essential Role of O-GlcNAcylation in Hepatic Differentiation

D. R. Robarts, M. Kotulkar, D. Paine-Cabrera, K. K. Venneman, J. A. Hanover, N. E. Zachara, C. Slawson, U. Apte

This study shows that O-GlcNAcylation is essential for hepatocyte differentiation and its loss promotes liver fibrosis and hepatocellular carcinoma.

bioRxiv · Feb 16, 2023Pathology

Identifying Human Specific Adverse Outcome Pathways of Per- and Polyfluoroalkyl Substances Using Liver-Chimeric Humanized Mice

D. R. Robarts, D. Paine-Cabrera, M. Kotulkar, K. K. Venneman, S. Gunewardena, J. C. Corton, C. Lau, L. Foquet, G. Bial, U. Apte

This study uses liver-chimeric humanized mice to identify human-specific adverse hepatic effects of PFAS, finding NR1D1 inhibition as a common molecular mechanism.

bioRxiv · Feb 1, 2023 · PreprintPharmacology & Toxicology