M. Kotulkar

Multi-Omics after O-GlcNAc Alteration Identifies Cellular Processes Working Synergistically to Promote Aneuploidy

The paper uses multi-omics analysis to show OGT regulates aneuploidy by fine-tuning multiple cellular pathways through O-GlcNAcylation.

Role of HNF4alpha-cMyc Interaction in CDE-diet Induced Liver Injury and Regeneration

This study examines the role of HNF4-cMyc interaction in liver injury and regeneration using a CDE diet model, finding that HNF4 deletion increases injury while cMyc deletion decreases it, with combined deletion leading to a unique HPC activation phenotype.

Regulation of Hepatic Xenosensor Function by HNF4alpha

This study shows that HNF4alpha is essential for the function of CAR, PXR, and PPAR but not AhR in hepatic xenosensor activation.

The Essential Role of O-GlcNAcylation in Hepatic Differentiation

This study shows that O-GlcNAcylation is essential for hepatocyte differentiation and its loss promotes liver fibrosis and hepatocellular carcinoma.

Identifying Human Specific Adverse Outcome Pathways of Per- and Polyfluoroalkyl Substances Using Liver-Chimeric Humanized Mice

This study uses liver-chimeric humanized mice to identify human-specific adverse hepatic effects of PFAS, finding NR1D1 inhibition as a common molecular mechanism.

Regulation of Liver Regeneration by hepatocyte O-GlcNAcylation in mice

This study shows that O-GlcNAcylation in hepatocytes is essential for proper liver regeneration, with its loss leading to uncontrolled proliferation and tumor formation.