Author

D. R. Maestas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:clustering· 1

Frequent Co-Authors

J. H. Elisseeff· 4 shared D. M. Pardoll· 3 shared E. Moore· 3 shared F. Housseau· 3 shared C. Cherry· 2 shared J. C. Mejias· 2 shared J. Han· 2 shared K. Krishnan· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBioengineering

J. H. Elisseeff

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Author profile →

4 papers

Recent·Most cited

Helminth egg derivatives as pro-regenerative immunotherapies

D. R. Maestas, L. Chung, J. Han, X. Wang, S. D. Sommerfeld, E. Moore, H. Hieu Nguyen, J. C. Mejias, A. N. Pena, H. Zhang, J. S. T. Hooks, A. F. Chin, J. I. Andorko, C. Berlicke, K. Krishnan, , J. H. Elisseeff

This study develops a regenerative immunotherapy using helminth-derived soluble egg antigen to promote tissue repair in multiple injury models.

bioRxiv · May 2, 2022 · PreprintBioengineering

Age-associated Senescent - T Cell Signaling Promotes Type 3 Immunity that Inhibits Regenerative Response

J. Han, C. Cherry, J. C. Mejias, A. Ruta, D. R. Maestas, A. Pena, H. H. Nguyen, B. Yang, E. Gray-Gaillard, N. Rutkowski, K. Krishnan, A. J. Tam, E. J. Fertig, F. Housseau, S. Ganguly, , J. H. Elisseeff

This study shows that age-related senescent T cells promote type 3 immunity, which inhibits tissue repair, and that blocking this pathway improves healing in older animals.

bioRxiv · Aug 17, 2021 · PreprintBioengineering

Biomaterials direct functional B cell response in a material specific manner

E. Moore, D. R. Maestas, C. C. Cherry, J. A. Garcia, H. Y. Comeau, L. Davenport Huyer, R. L. Blosser, G. D. Rosson, J. H. Elisseeff

This study shows that biomaterial composition influences B cell responses, with ECM materials inducing plasmablasts and antigen presentation, while synthetic PCL delays B cell migration and induces antigen-presenting phenotypes.

bioRxiv · Jan 12, 2021Bioengineering

Single cell RNA-seq in regenerative and fibrotic biomaterial environments defines new macrophage subsets

S. D. Sommerfeld, C. Cherry, R. M. Schwab, L. Chung, D. R. Maestas, P. Laffont, J. E. Stein, A. Tam, F. Housseau, J. M. Taube, D. M. Pardoll, P. Cahan, J. H. Elisseeff

The paper uses single-cell RNA sequencing to identify distinct macrophage subsets in regenerative and fibrotic environments, revealing new phenotypes and potential therapeutic targets.

bioRxiv · May 20, 2019Immunology