Author

S. Chimalapati

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

K. Orth· 5 shared K. G. Kaval· 2 shared L. N. Kinch· 2 shared A. B. Dalia· 1 shared A. Blevins· 1 shared A. E. Lafrance· 1 shared A. K. Casey· 1 shared A. Lafrance· 1 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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5 shared papersMicrobiology

K. Orth

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular Determinants for Differential Activation of the Vibrio parahaemolyticus Bile Acid Receptor

A. Zou, L. N. Kinch, S. Chimalapati, N. Garcia Rodriguez, D. R. Tomchick, K. Orth

This study identifies molecular determinants for differential activation of the Vibrio parahaemolyticus bile acid receptor by showing how specific bile acids bind to the VtrA/VtrC complex and influence pathogenic gene expression.

bioRxiv · Sep 2, 2022 · PreprintMicrobiology

Enzymatic Specificity of Conserved Rho GTPase Deamidases Promotes Invasion of Vibrio parahaemolyticus at the Expense of Infection

K. Orth, A. E. Lafrance, S. Chimalapati, N. M. Garcia-Rodriguez, L. N. Kinch, K. G. Kaval

This study shows that CNF1 enhances V. parahaemolyticus invasion but fails to complete infection, while VopC allows efficient invasion and infection completion, highlighting the importance of enzymatic specificity in bacterial pathogenesis.

bioRxiv · Jun 13, 2022Microbiology

Fic-mediated AMPylation tempers the Unfolded Protein Response during physiological stress

A. K. Casey, H. F. Gray, S. Chimalapati, G. Hernandez, A. Moehlman, N. Stewart, H. A. Fields, B. Gulen, K. A. Servage, K. Stefanius, A. Blevins, E. Daoud, B. M. Evers, H. Kramer, K. Orth

This study shows that Fic-mediated AMPylation regulates the UPR response in the pancreas during stress, preventing excessive inflammation and damage.

bioRxiv · Apr 27, 2022Physiology

Transertion is used for localized expression and assembly of Vibrio parahaemolyticus T3SS2

K. G. Kaval, S. Chimalapati, S. Seigel, N. G. Rodriguez, A. B. Dalia, K. Orth

The paper shows Vibrio parahaemolyticus uses transertion to assemble T3SS2 in response to bile acids.

bioRxiv · Feb 23, 2022 · PreprintMicrobiology

Vibrio deploys Type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

M. de Souza Santos, S. Chimalapati, A. Ray, W.-R. Lee, G. Rivera-Cancel, A. Lafrance, G. Vale, M. Mitsche, J. G. McDonald, J. Liou, K. Orth

This study identifies VPA0226, a lipase secreted by Vibrio parahaemolyticus, which esterifies cholesterol with host fatty acids to weaken the plasma membrane and enable bacterial egress from host cells.

bioRxiv · Nov 12, 2019Microbiology