Author

D. Ruan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Immunology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:clustering· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

K. Tang· 2 shared P. Liu· 2 shared S. Yuan· 2 shared A. M. Lipzen· 1 shared A. To· 1 shared C. P. Ong· 1 shared C. W. Chau· 1 shared C. Wen· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

K. Tang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Necessity and Impact of Specialization of Large Foundation Model for Medical Segmentation Tasks

E. Nguyen, H. Liu, D. Ruan

This study evaluates MedSAM and LiteMedSAM for medical image segmentation, finding that off-the-shelf performance is poor but specialized fine-tuning significantly improves accuracy.

bioRxiv · Jun 2, 2024Bioengineering

SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids

C. W. Chau, A. To, R. K. H. Au-Yeung, K. Tang, Y. Xiang, D. Ruan, L. Zhang, H. Wong, S. Zhang, M. T. Au, S. Chung, E. Song, D.-H. Choi, P. Liu, S. Yuan, , R. Sugimura

This study shows SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids, upregulating interferon signaling linked to cytokine release syndrome.

Scientific Reports · Apr 16, 2024Peer-reviewedImmunology

Human Early Syncytiotrophoblasts Are Highly Susceptible to SARS-CoV-2 Infection

P. Liu, D. RUAN, Z.-W. Ye, S. Yuan, Z. Li, W. Zhang, C. P. Ong, K. Tang, J. Guo, Y. Xuan, T. T. K. K. Tam, Y. Huang, Q. Zhang, C.-L. Lee, P. C. N. Chiu, , D.-Y. Jin

This paper shows that human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection via ACE2 and demonstrates antiviral efficacy of remdesivir and GC376.

bioRxiv · Nov 17, 2022Cell Biology

The Sequence of 1504 Mutants in the Model Rice Variety Kitaake Facilitates Rapid Functional Genomic Studies

G. Li, R. Jain, M. Chern, N. T. Pham, J. A. Martin, T. Wei, W. S. Schackwitz, A. M. Lipzen, P. Q. Duong, K. C. Jones, L. Jiang, D. Ruan, D. Bauer, Y. Peng, K. W. Barry, , P. C. Ronald

The paper sequenced 1,504 mutant lines in the rice variety Kitaake and established a database to enable rapid functional genomic studies.

bioRxiv · Feb 24, 2017Plant Biology