K. Kawakami

Structure of PSI-LHCI from Cyanidium caldarium provides evolutionary insights into conservation and diversity of red-lineage LHCs

The paper determines the structure of PSI-LHCI from Cyanidium caldarium and investigates its evolutionary relationships with other red-lineage LHCs.

Phosphorylation barcodes direct biased chemokine signaling at CXCR3

The paper shows that CXCR3 chemokines use different phosphorylation barcodes to activate distinct signaling pathways, leading to varied physiological outcomes.

Structure of a monomeric photosystem I core associated with iron-stress-induced-A proteins from Anabaena sp. PCC 7120

The paper determines the structure of a monomeric photosystem I core complex with IsiA proteins from Anabaena sp. PCC 7120 under iron deficiency, revealing their role in inhibiting PSI oligomerization.

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

This study characterizes the biased agonism of CXCR4 and CXCR7, revealing differences in G-protein coupling, β-arrestin recruitment, and ERK1/2 activation.

Hydrogen properties and charges in a sub-1.2 A resolution cryo-EM structure revealed by a cold field emission beam

Core and rod structures of a thermophilic cyanobacterial light-harvesting phycobilisome

The paper reports cryo-EM structures of a thermophilic cyanobacterial phycobilisome, revealing protein subunit arrangements and energy transfer pathways.

Membrane phosphoinositides stabilize GPCR-arrestin complexes and offer temporal control of complex assembly and dynamics

This study identifies membrane phosphoinositides as regulators of GPCR-arrestin complex dynamics, showing they stabilize complexes and enable temporal control of receptor signaling and recycling.

Structural basis for the absence of low-energy chlorophylls responsible for photoprotection from a primitive cyanobacterial PSI

The paper solves the structure of a cyanobacterial PSI lacking low-energy chlorophylls, revealing their absence and functional roles in photoprotection and evolution.

Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors

The paper identifies two non-canonical GPCRs, D6R and C5aR2, that exclusively couple to β-arrestins and exhibit distinct GRK preferences and downstream signaling.

Innervation modulates the functional connectivity between pancreatic endocrine cells

This study shows that innervation modulates functional connectivity between pancreatic endocrine cells, with delta cells receiving innervation that coordinates their activity.

Heterotypic inter-GPCR β-arrestin coupling regulates lymphatic endothelial junctional architecture in murine lymph nodes

The paper identifies LPAR1-induced S1PR1/β-arrestin coupling as a mechanism regulating lymphatic endothelial junctional architecture in murine lymph nodes.

A novel zebrafish intestinal tumor model reveals a role for cyp7a1-dependent tumor-liver crosstalk in tumor's adverse effects on host

This study establishes a zebrafish intestinal tumor model and identifies cyp7a1 as a host gene involved in tumor-induced liver inflammation through bile acid metabolism disruption.