Author

D. Shorthouse

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biophysics· 3

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

B. A. Hall· 7 shared M. W. J. Hall· 3 shared A. Riedel· 1 shared A. S. H. Costa· 1 shared B. Greenwood· 1 shared C. Bendtsen· 1 shared C. Frezza· 1 shared C. Kosmidou· 1 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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7 shared papersCancer Biology

B. A. Hall

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7 papers

Recent·Most cited

Heterogeneity of the Cancer Cell Line Metabolic Landscape

D. Shorthouse, J. Bradley, S. Critchlow, C. Bendtsen, B. A. Hall

This study analyzes the metabolic profiles of 173 cancer cell lines to correlate metabolic signatures with genetic mutations and drug response, revealing tissue-specific metabolic control.

bioRxiv · Aug 19, 2021Cancer Biology

SARS-CoV-2 Variants are Selecting for Spike Protein Mutations that Increase Protein Stability

D. Shorthouse, B. A. Hall

This study identifies that SARS-CoV-2 variants are selecting for spike protein mutations that increase protein stability, suggesting stability as a key factor in viral evolution.

bioRxiv · Jun 25, 2021Biophysics

HOXA9 acts as a regulatory switch in acute myeloid leukaemia and myeloproliferative neoplasms

L. Talarmain, M. A. Clarke, D. Shorthouse, J. Fisher, B. A. Hall

The paper investigates HOXA9's role in AML and MPN, showing it acts as a regulatory switch affecting prognosis and clinical outcomes through interactions with JAK2, TET2, RUNX1, and NOTCH.

bioRxiv · Mar 5, 2021Cancer Biology

Investigating structure function relationships in the NOTCH family through large-scale somatic DNA sequencing studies

M. W. J. Hall, D. Shorthouse, P. Jones, B. A. Hall

The paper analyzes missense mutations in NOTCH1 and NOTCH2 in human oesophageal epithelium to infer structure-function relationships through in vivo selection pressures.

bioRxiv · Mar 31, 2020 · PreprintBiophysics

THE ROLE OF POTASSIUM CHANNELS IN THE PATHOGENESIS OF GASTROINTESTINAL CANCERS AND THERAPEUTIC POTENTIAL

D. Shorthouse, J. L. Zhuang, E. Rahrmann, C. Kosmidou, K. W. Rahrmann, M. W. J. Hall, B. Greenwood, G. Devonshire, R. Gilbertson, R. Fitzgerald, B. A. Hall

The paper identifies KCNQ channel mutations in 30% of gastrointestinal cancers and shows their therapeutic targetability through drug sensitivity and proliferation inhibition.

bioRxiv · Mar 10, 2020 · PreprintCancer Biology

The Landscape of Mutations in Fumarate Hydratase

D. Shorthouse, M. W. J. Hall, B. A. Hall

The paper predicts the functional effects of FH mutations, identifies mutational hotspots, and categorizes mutations based on their functional impact using computational methods and metabolomics validation.

bioRxiv · Jan 31, 2020Biophysics

Tumor pre-conditioning of draining lymph node stroma by lactic acid

A. Riedel, J. Swietlik, D. Shorthouse, L. Haas, T. Young, A. S. H. Costa, S. Davidson, L. Pedro, T. Oskarsson, B. A. Hall, C. Frezza, J. Shields

This study identifies lactate as a tumor-derived metabolite that reprograms fibroblastic reticular cells in draining lymph nodes, altering their function and similarity to tumor-associated fibroblasts.

bioRxiv · Oct 12, 2018Cancer Biology