Author

M. W. J. Hall

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

B. A. Hall· 5 shared D. Shorthouse· 3 shared P. Jones· 2 shared B. Greenwood· 1 shared C. Kosmidou· 1 shared C. W. Siebel· 1 shared E. Abby· 1 shared E. Rahrmann· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersCancer Biology

B. A. Hall

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Author profile →

5 papers

Recent·Most cited

Notch1 mutation drives clonal expansion in normal esophageal epithelium but impairs tumor growth

E. Abby, S. C. Dentro, M. W. J. Hall, J. C. Fowler, S. H. Ong, R. Sood, C. W. Siebel, M. Gerstung, B. A. Hall, P. Jones

The paper shows NOTCH1 mutations promote clonal expansion in normal esophageal epithelium but hinder tumor growth, suggesting NOTCH1 inhibition could prevent esophageal squamous cancer.

bioRxiv · Jun 18, 2021 · PreprintCancer Biology

Investigating structure function relationships in the NOTCH family through large-scale somatic DNA sequencing studies

M. W. J. Hall, D. Shorthouse, P. Jones, B. A. Hall

The paper analyzes missense mutations in NOTCH1 and NOTCH2 in human oesophageal epithelium to infer structure-function relationships through in vivo selection pressures.

bioRxiv · Mar 31, 2020 · PreprintBiophysics

THE ROLE OF POTASSIUM CHANNELS IN THE PATHOGENESIS OF GASTROINTESTINAL CANCERS AND THERAPEUTIC POTENTIAL

D. Shorthouse, J. L. Zhuang, E. Rahrmann, C. Kosmidou, K. W. Rahrmann, M. W. J. Hall, B. Greenwood, G. Devonshire, R. Gilbertson, R. Fitzgerald, B. A. Hall

The paper identifies KCNQ channel mutations in 30% of gastrointestinal cancers and shows their therapeutic targetability through drug sensitivity and proliferation inhibition.

bioRxiv · Mar 10, 2020 · PreprintCancer Biology

The Landscape of Mutations in Fumarate Hydratase

D. Shorthouse, M. W. J. Hall, B. A. Hall

The paper predicts the functional effects of FH mutations, identifies mutational hotspots, and categorizes mutations based on their functional impact using computational methods and metabolomics validation.

bioRxiv · Jan 31, 2020Biophysics

Relating evolutionary selection and mutant clonal dynamics in normal epithelia

M. W. J. Hall, P. H. Jones, B. A. Hall

The paper analyzes mutant clonal dynamics in normal epithelia to determine if mutations confer a competitive advantage, showing that previous metrics may misrepresent non-neutral behavior due to experimental design and tissue constraints.

bioRxiv · Mar 8, 2019Cancer Biology