B. A. Hall

Coxiella burnetii-containing vacuoles interact with host recycling-endosomal proteins Rab11a and Rab35 for vacuolar expansion

This study shows Coxiella burnetii-containing vacuoles interact with host Rab11a and Rab35 for vacuolar expansion, with Rab11a and Rab35 expression patterns changing over infection stages.

p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition

This study shows p53 mutations in normal esophagus drive clonal expansion but are constrained by clonal competition, and LOH is critical for malignant transformation.

Heterogeneity of the Cancer Cell Line Metabolic Landscape

This study analyzes the metabolic profiles of 173 cancer cell lines to correlate metabolic signatures with genetic mutations and drug response, revealing tissue-specific metabolic control.

SARS-CoV-2 Variants are Selecting for Spike Protein Mutations that Increase Protein Stability

This study identifies that SARS-CoV-2 variants are selecting for spike protein mutations that increase protein stability, suggesting stability as a key factor in viral evolution.

Precancer: Mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors

The paper shows that mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors through cell competition, preventing tumor formation.

Notch1 mutation drives clonal expansion in normal esophageal epithelium but impairs tumor growth

The paper shows NOTCH1 mutations promote clonal expansion in normal esophageal epithelium but hinder tumor growth, suggesting NOTCH1 inhibition could prevent esophageal squamous cancer.

HOXA9 acts as a regulatory switch in acute myeloid leukaemia and myeloproliferative neoplasms

The paper investigates HOXA9's role in AML and MPN, showing it acts as a regulatory switch affecting prognosis and clinical outcomes through interactions with JAK2, TET2, RUNX1, and NOTCH.

Investigating structure function relationships in the NOTCH family through large-scale somatic DNA sequencing studies

The paper analyzes missense mutations in NOTCH1 and NOTCH2 in human oesophageal epithelium to infer structure-function relationships through in vivo selection pressures.

THE ROLE OF POTASSIUM CHANNELS IN THE PATHOGENESIS OF GASTROINTESTINAL CANCERS AND THERAPEUTIC POTENTIAL

The paper identifies KCNQ channel mutations in 30% of gastrointestinal cancers and shows their therapeutic targetability through drug sensitivity and proliferation inhibition.

The Landscape of Mutations in Fumarate Hydratase

The paper predicts the functional effects of FH mutations, identifies mutational hotspots, and categorizes mutations based on their functional impact using computational methods and metabolomics validation.

The single-progenitor model as the unifying paradigm of squamous epithelial maintenance

This study uses lineage tracing and proliferation assays to show that squamous epithelial tissues are maintained by a single population of proliferating cells, not multiple stem cell types.

Relating evolutionary selection and mutant clonal dynamics in normal epithelia

The paper analyzes mutant clonal dynamics in normal epithelia to determine if mutations confer a competitive advantage, showing that previous metrics may misrepresent non-neutral behavior due to experimental design and tissue constraints.

Tumor pre-conditioning of draining lymph node stroma by lactic acid

This study identifies lactate as a tumor-derived metabolite that reprograms fibroblastic reticular cells in draining lymph nodes, altering their function and similarity to tumor-associated fibroblasts.