Author

J. C. Aster

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

S. C. Blacklow· 5 shared J. A. Marto· 2 shared J. M. Rogers· 2 shared L. Pan· 2 shared L. Tveriakhina· 2 shared R. Cao· 2 shared S. Wang· 2 shared A. De Martin· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersBiochemistry

S. C. Blacklow

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Structural Requirements for Activity of Mind bomb1 in Notch Signaling

R. Cao, O. Gozlan, L. Tveriakhina, H. Zhou, H. Jiang, P. A. Cole, J. C. Aster, D. Sprinzak, S. C. Blacklow

This study identifies the structural requirements of MIB1 for ubiquitin transfer in Notch signaling, showing that RING3 is essential for catalytic activity and dimerization.

bioRxiv · Mar 1, 2024Biochemistry

Temporal Dynamics and Stoichiometry in Notch Signaling - from Notch Synaptic Complex Formation to NICD Nuclear Entry

L. Tveriakhina, G. Scanavachi, E. D. Egan, R. B. D. C. Correia, A. P. Martin, J. M. Rogers, J. S. Yodh, J. C. Aster, T. Kirchhausen, S. C. Blacklow

This study tracks Notch and Delta interactions in real-time, showing 1:1 stoichiometry at synapses and NICD nuclear entry after 45 minutes, inhibited by signaling blockers.

bioRxiv · Sep 27, 2023 · PreprintCell Biology

Molecular Mechanism of PP2A/B55α Phosphatase Inhibition by IER5

R. Cao, D. T. Jones, L. Pan, S. Wang, S. K. R. Padi, S. Rawson, J. C. Aster, S. C. Blacklow

This study determines the structure of PP2A/B55 inhibited by IER5-N50 and shows its role in suppressing pTau dephosphorylation and KRT1 expression.

bioRxiv · Aug 29, 2023Biochemistry

A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease

J. D. Brandstadter, A. De Martin, M. Lutge, A. Ferreira, B. T. Gaudette, Y. Stanossek, S. Wang, M. V. Gonzalez, E. Camiolo, G. Wertheim, B. Austin, D. Allman, M. S. Lim, D. C. Fajgenbaum, J. C. Aster, , I. Maillard

This study demonstrates that cryopreservation of lymphoid tissue allows for the study of non-hematopoietic stromal cells in human disease, preserving cell type proportions and transcriptional profiles.

bioRxiv · Feb 6, 2023Immunology

IER5, a DNA-damage response gene, is required for Notch-mediated induction of squamous cell differentiation

L. Pan, M. E. Lemieux, T. Thomas, J. M. Rogers, W. Lee, C. Johnson, L. Sholl, A. P. South, J. A. Marto, G. O. Adelmant, S. C. Blacklow, J. C. Aster

The paper identifies IER5 as a Notch-induced DNA-damage response gene required for squamous cell differentiation and shows its interaction with PP2A subunit PPP2R2A.

bioRxiv · Apr 21, 2020Cancer Biology

A Germinal Center-Associated Microenvironmental Signature Reflects Malignant Phenotype and Outcome of Diffuse Large B-cell Lymphoma

K. Miyawaki, K. Kato, T. Sugio, K. Sasaki, H. Miyoshi, Y. Semba, Y. Kikushige, Y. Mori, Y. Kunisaki, H. Iwasaki, T. Miyamoto, F. C. Kuo, J. C. Aster, K. Ohshima, T. Maeda, K. Akashi

The paper identifies a germinal center-associated microenvironmental signature in DLBCL that correlates with prognosis and molecular features, showing its impact on clinical outcomes.

bioRxiv · Nov 7, 2019 · PreprintCancer Biology

Molecular basis for feedback inhibition of Notch signaling by the Notch regulated ankyrin repeat protein NRARP

S. M. Jarrett, T. C. M. Seegar, M. Andrews, G. Adelmant, J. A. Marto, J. C. Aster, S. C. Blacklow

This study identifies the molecular mechanism by which NRARP inhibits Notch signaling by binding to the NTC complex and disrupting its function.

bioRxiv · May 23, 2019 · PreprintBiochemistry