ARF6-dependent endocytic trafficking of the Interferon-γ receptor drives adaptive immune resistance in cancer.
Y. Wee, J. Wang, E. C. Wilson, C. P. Rich, A. Rogers, Z. Tong, E. DeGroot, Y. N. V. Gopal, M. A. Davies, H. A. Ekiz, J. K. H. Tay, C. Stubben, K. M. Boucher, J. M. Oviedo, K. Fairfax, , A. H. Grossmann
This study identifies ARF6-dependent endocytic trafficking of the IFN-gamma receptor as a mechanism driving adaptive immune resistance in cancer, linking it to immune checkpoint blockade efficacy.
bioRxiv · Sep 29, 2023Cancer Biology