Author

R. C. Charles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

E. T. Ryan· 4 shared A. I. Khan· 3 shared F. Qadri· 3 shared R. C. LaRocque· 3 shared A. A. Weil· 2 shared F. Chowdhury· 2 shared J. B. Harris· 2 shared M. Kamruzzaman· 2 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

E. T. Ryan

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Shigella O-specific polysaccharide functional IgA responses mediate protection against shigella infection in an endemic high-burden setting

B. Bernshtein, M. Kelly, D. Cizmeci, J. A. Zhiteneva, R. Macvicar, M. Kamruzzaman, T. R. Bhuiyan, F. Chowdhury, A. I. Khan, F. Qadri, R. C. Charles, P. Xu, P. Kovac, R. W. Kaminski, G. Alter, E. T. Ryan

This study identifies OSP-specific functional IgA responses as protective against shigella infection in high-burden settings by enhancing neutrophil and monocyte activation.

bioRxiv · May 4, 2023Immunology

Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates

N. Zabaleta, W. Dai, U. Bhatt, J. A. Chichester, J. Sanmiguel, R. Estelien, K. T. Michalson, C. Diop, D. Maciorowski, W. Qi, E. Hudspeth, A. Cucalon, C. D. Dyer, M. B. Pampena, J. J. Knox, , L. H. Vandenberghe

This paper evaluates an AAV-based COVID-19 vaccine in mice and non-human primates, showing sustained neutralizing antibodies and memory T-cells, with room-temperature stability and scalable production.

bioRxiv · Jan 5, 2021 · PreprintImmunology

Humans surviving cholera develop antibodies against Vibrio cholerae O-specific polysaccharide that inhibit pathogen motility

R. C. Charles, M. Kelly, J. M. Tam, A. Akter, M. Hossain, K. Islam, R. Biswas, M. Kamruzzaman, F. Chowdhurry, A. I. Khan, D. T. Leung, A. A. Weil, R. C. LaRocque, T. R. Bhuiyan, A. Rahman, , E. T. Ryan

This study shows that antibodies against Vibrio cholerae O-specific polysaccharide inhibit bacterial motility and provide protection against cholera in a murine model.

bioRxiv · Oct 8, 2020Microbiology

Vibrio cholerae genomic diversity within and between patients

I. Levade, Y. Terrat, J.-B. Leducq, A. A. Weil, L. M. Mayo-Smith, F. Chowdhury, A. I. Khan, J. Boncy, J. Buteau, L. C. Ivers, E. T. Ryan, R. C. Charles, S. B. Calderwood, F. Qadri, J. B. Harris, , B. J. Shapiro

This study examines V. cholerae genomic diversity within and between patients, finding limited point mutations but higher gene content variation, including phage and plasmid exchanges, which may impact disease outcomes.

Microbial Genomics · Dec 7, 2017Peer-reviewedMicrobiology