Exposure of mammary cells to lipid activates gene expression changes associated with ER-negative breast cancer via chromatin remodeling.
S. Yadav, R. Virk, C. Chung, D. Van Derway, D. Chen, K. Burdett, H. Gao, Z. Zeng, M. Ranjan, G. Cottone, X. Xuei, S. Chandrasekaran, V. Backman, R. Chaterton, S. Khan, S. Clare
The paper shows lipid exposure alters gene expression and chromatin features in mammary cells, linking these changes to ER-negative breast cancer development.
bioRxiv · Dec 13, 2020 · PreprintCancer Biology