C. Chung

Targeting Neutrophil Extracellular Traps to inhibit Colon Cancer Tumor Necrosis and Metastasis

This study shows that neutrophil extracellular traps (NETs) drive tumor necrosis and metastasis in colorectal cancer, and inhibiting NET formation reduces necrosis and improves chemotherapy outcomes.

Fig4 confers tolerance to rapamycin in a Ste20-dependent manner independent of the Vac14 scaffold

The paper shows that Fig4 mutants in yeast confer rapamycin tolerance independently of Vac14 through Ste20-dependent mechanisms, suggesting Fig4 functions outside the Fab1-Vac14-Fig4 complex.

Potential Opportunities of Modeling Bioavailability for Monoclonal Antibodies: An Overview of mAbs and the current challenges of mAb development

This paper reviews 10 monoclonal antibodies, analyzes their pharmacokinetic and pharmacodynamic properties, and uses a machine learning model to assess subcutaneous bioavailability and optimize drug delivery.

Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness

This study shows that senolytic CAR T cells remove senescent cells in the aging gut, improving intestinal regeneration and immune function.

Therapeutic targeting of differentiation state-dependent metabolic vulnerabilities in DIPG

This study identifies metabolic vulnerabilities in DIPG subtypes and shows that targeting these vulnerabilities with specific drugs can extend survival in preclinical models.

Stress-induced collective behavior leads to the formation of multicellular structures and the survival of the unicellular alga Chlamydomonas

The paper identifies a stress-induced mechanism in Chlamydomonas that leads to multicellular structure formation, showing it provides protection and involves genetic reprogramming and secretome changes.

Exposure of mammary cells to lipid activates gene expression changes associated with ER-negative breast cancer via chromatin remodeling.

The paper shows lipid exposure alters gene expression and chromatin features in mammary cells, linking these changes to ER-negative breast cancer development.

Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis

The paper shows that a high fat diet reduces MHC-II expression in intestinal stem cells, promoting tumorigenesis by altering immune recognition.

Identification and Characterization of a B-Raf Kinase Alpha Helix Critical for the Activity of MEK Kinase in MAPK Signaling

The paper identifies an alpha helix on B-Raf critical for its interaction with MEK and oncogenic activity, suggesting it as a potential drug target for melanoma treatment.

FAIRsharing, a cohesive community approach to the growth in standards, repositories and policies

The paper introduces FAIRsharing, a community-driven resource that evaluates and promotes standards, databases, and repositories to improve data reuse and interoperability in research.