Author

S. Clare

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 2 Pharmacology & Toxicology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:mouse· 8 Research Focus:host-pathogen & immune response· 7 Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2

Frequent Co-Authors

C. Brandt· 6 shared K. Harcourt· 5 shared G. Dougan· 3 shared B. Moron· 2 shared C. Tolley· 2 shared G. Notley· 2 shared I. Humphreys· 2 shared M. Berriman· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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6 shared papersImmunology

C. Brandt

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

A drug repurposing screen for whipworms informed by comparative genomics

A. Coghlan, F. A. Partridge, M. A. Duque-Correa, G. Rinaldi, S. Clare, L. Seymour, C. Brandt, T. T. Mkandawire, C. McCarthy, N. Holroyd, M. Nick, A. E. Brown, S. Tonitiwong, D. B. Sattelle, M. Berriman

This paper identifies potential anti-whipworm drugs by testing approved human drugs ex vivo and in vivo, finding limited efficacy due to pharmacokinetic challenges.

bioRxiv · Mar 2, 2023Pharmacology & Toxicology

Inhibition of Aromatase by Hops, Licorice Species, and their bioactive compounds in Postmenopausal Breast Tissue

A. Hajirahimkhan, C. E. Howell, S.-N. Chen, S. Clare, G. Pauli, S. Khan, J. L. Bolton, B. M. Dietz

The paper investigates the aromatase inhibitory effects of hops, licorice species, and their bioactive compounds in postmenopausal breast tissue, identifying potent inhibitors with potential for breast cancer prevention.

bioRxiv · May 6, 2022 · PreprintPharmacology & Toxicology

Inhibitory IL-10-producing CD4+ T cells develop in a T-bet-dependent manner and facilitate cytomegalovirus persistence via coexpression of arginase-1

M. Clement, K. Ladell, K. L. Miners, M. Marsden, L. Chapman, A. Cardus-Figueras, J. Scott, R. Andrews, S. Clare, V. V. Kriukova, K. R. Lupyr, O. V. Britanova, D. R. Withers, D. M. Chudakov, S. A. Jones, , I. Humphreys

The paper identifies IL-10-producing CD4+ T cells that develop via T-bet dependence and Arg1 coexpression, promoting cytomegalovirus persistence.

bioRxiv · Jan 25, 2022Immunology

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

L. O. Randzavola, P. M. Mortimer, E. C. Garside, E. R. Dufficy, A. Schejtman, G. Roumelioti, L. Yu, M. Pardo, K. Spirohn, C. Tolley, C. Brandt, K. Harcourt, E. Nichols, M. Nahorski, G. Woods, , D. C. Thomas

This study identifies EROS as a chaperone essential for gp91phox maturation and P2X7 receptor function, revealing its role in immune responses and infection resistance.

bioRxiv · Sep 14, 2021Immunology

IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses

M. Clement, J. L. Forbester, M. Marsden, P. Sabberwal, D. Wellington, S. Dimonte, K. Harcourt, S. Clare, Z. Yin, L. Nobre, R. Antrobus, B. Jin, M. Chen, S. Makvandi-Nejad, J. A. Lindborg, , I. Humphreys

This study shows IFITM3 limits viral pathogenesis by regulating Nogo-B-mediated TLR responses and cytokine production in dendritic cells.

bioRxiv · Jul 23, 2021 · PreprintImmunology

An invariant Trypanosoma vivax vaccine antigen inducing protective immunity

D. Autheman, C. Crosnier, S. Clare, D. Goulding, C. Brandt, K. Harcourt, C. Tolley, F. Galaway, M. Khushu, H. Ong, A. Romero Ramirez, C. Duffy, A. Jackson, G. J. Wright

This study identifies an invariant Trypanosoma vivax antigen that induces protective immunity through vaccination and monoclonal antibodies.

bioRxiv · Feb 10, 2021Microbiology

Novel gut pathobionts confound results in a widely used mouse model of human inflammatory disease

S. C. Forster, S. Clare, B. S. Beresford-Jones, K. Harcourt, G. Notley, M. Stares, N. Kumar, A. T. Soderholm, A. Adoum, H. Wong, B. Moron, C. Brandt, G. Dougan, D. J. Adams, K. J. Maloy, , T. D. Lawley

The paper identifies two novel gut bacteria that influence disease variability in a mouse model of inflammatory bowel disease.

bioRxiv · Feb 9, 2021 · PreprintMicrobiology

Exposure of mammary cells to lipid activates gene expression changes associated with ER-negative breast cancer via chromatin remodeling.

S. Yadav, R. Virk, C. Chung, D. Van Derway, D. Chen, K. Burdett, H. Gao, Z. Zeng, M. Ranjan, G. Cottone, X. Xuei, S. Chandrasekaran, V. Backman, R. Chaterton, S. Khan, S. Clare

The paper shows lipid exposure alters gene expression and chromatin features in mammary cells, linking these changes to ER-negative breast cancer development.

bioRxiv · Dec 13, 2020 · PreprintCancer Biology

Rora regulates activated T helper cells during inflammation

V. Liora, J. A. Walker, J. Henriksson, Z. Miao, E. Natan, G. Kar, S. Clare, J. L. Barlow, E. Charidemou, L. Mamanova, X. Chen, V. Proserpio, J. Pramanik, S. Woodhouse, A. V. Protasio, , S. A. Teichmann

This study investigates Rora's role in CD4+ T cells during inflammation, finding it regulates lung inflammation and is controlled by IL-33 and CCL7.

bioRxiv · Jul 15, 2020 · PreprintImmunology

Interferon-induced Protein-44 and Interferon-induced Protein 44-like restrict replication of Respiratory Syncytial Virus

D. C. Busse, D. Habgood-Coote, S. Clare, C. Brandt, I. Bassano, M. Kafarou, J. Herberg, M. Levin, J.-F. Eleouet, P. Kellam, J. S. Tregoning

This study shows that IFI44 and IFI44L restrict RSV replication and are anti-viral and anti-proliferative, with IFI44L serving as a diagnostic marker for viral infection.

bioRxiv · Feb 24, 2020Immunology

High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

L. Abeler-Dörner, A. Laing, A. Lorenc, D. S. Ushakov, S. Clare, A. Speak, M. A. Duque Correa, J. K. White, R. Ramirez-Solis, N. Saran, K. R. Bull, B. Moron, J. Iwasaki, P. R. Barton, S. Caetano, , Edmans

This study uses high-throughput phenotyping of knockout mice to identify genetic factors and structural patterns influencing immune variation.

bioRxiv · Jul 10, 2019Immunology