Author

G. Cottone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

H. Gao· 2 shared X. Xuei· 2 shared A. B. M. M. K. Islam· 1 shared A. Delort· 1 shared C. Chung· 1 shared C. W. McCloskey· 1 shared D. Chen· 1 shared D. Van Derway· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

H. Gao

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Metabolic shift to serine pathway induced by lipids confers oncogenic properties in non-transformed breast cells

M. B. Eduardo, G. Cottone, C. W. McCloskey, S. Liu, M. P. Zappia, E. V. Benevolenskaya, A. B. M. M. K. Islam, M. V. Frolov, F. R. Palma, P. Gao, J. Setya, H. Gao, X. Xuei, R. Khokha, J. Locasale, , S. E. Clare

The paper shows that lipid metabolism, specifically through OA, shifts metabolic pathways in breast cells, increasing SAM and 2-HG, which contribute to oncogenic properties and epigenetic changes.

bioRxiv · Feb 21, 2024 · PreprintCancer Biology

Conformational Space of the Translocation Domain of Botulinum Toxin: Atomistic Modeling and Mesoscopic Description of the Coiled-Coil Helix Bundle

A. Delort, G. Cottone, T. E. Malliavin, M. M. Muller

The paper investigates the conformational changes of the translocation domain of botulinum toxin using atomistic simulations and the Twister model to understand its interaction with membranes.

bioRxiv · Feb 2, 2024Biophysics

Exposure of mammary cells to lipid activates gene expression changes associated with ER-negative breast cancer via chromatin remodeling.

S. Yadav, R. Virk, C. Chung, D. Van Derway, D. Chen, K. Burdett, H. Gao, Z. Zeng, M. Ranjan, G. Cottone, X. Xuei, S. Chandrasekaran, V. Backman, R. Chaterton, S. Khan, S. Clare

The paper shows lipid exposure alters gene expression and chromatin features in mammary cells, linking these changes to ER-negative breast cancer development.

bioRxiv · Dec 13, 2020 · PreprintCancer Biology